We report on a 63-year-old man with
myelodysplastic syndrome at the stage of a
refractory anemia with an excess of blasts in transformation (MDS-
RAEB-T), first diagnosed in December 1996. After a period of stability, with no need for transfusions, the MDS progressed into
acute myeloid leukemia (AML) in August 1998 with the emergence of a
cytogenetic abnormality (11q-). Two courses of
chemotherapy were given, resulting in prolonged
pancytopenia; however, no clearance of bone marrow (BM) blasts was achieved. At that time, severe
infections and daily
epistaxis occurred. Frequent transfusions of packed red blood cells (RBC) and platelets (2-3/week) were necessary. After 2 months of persisting severe
pancytopenia, we started a
therapy with
amifostine: 4 x 250 mg intravenously (i.v.) weekly for 1 month, followed by a maintenance
therapy with 500 mg once weekly. After 2 weeks of
amifostine therapy, hematopoiesis began to improve. In the subsequent 2 months, the patient became completely independent of the
platelet transfusions; the transfusion frequency of RBC was permanently reduced (2 RBC transfusions/month) and a significant decrease of BM blasts was achieved. After 30 weeks of
amifostine therapy, the morphology of the MDS switched to a
chronic myelomonocytic leukemia (CMML)-like appearance, with continuously increasing leukocytes, so that we discontinued
amifostine therapy for 1 month to exclude a possible side effect of
amifostine. At that time, leukocytes further increased to 74,000/microl; thus, we decided to perform a cytoreductive
chemotherapy (hydroxycarbamide) and continued weekly
amifostine infusions. During 1 year of
amifostine therapy, the patient had a good quality of life, with no need for hospitalization and a complete cytogenetic remission. We conclude that, in this case,
amifostine had two effects: a significant improvement of impaired hematopoiesis and a slowing down of
disease progression. Thus,
amifostine might be a therapeutic option in older patients with advanced MDS.