[In vitro comparative activity of moxifloxacin and other antimicrobials against respiratory pathogens].

Abstract

BACKGROUND:

Respiratory pathogens are becoming increasingly resistant to antimicrobials. A new group of drugs, called respiratory quinolones have been synthesized to overcome this problem.

AIM:

To study the in vitro susceptibility of respiratory pathogens to old and new antimicrobials.

MATERIALS AND METHODS:

Forty five strains of S pneumoniae, 44 strains of H influenzae, 21 strains of M catarrhalis, 10 strains of methicillin susceptible S aureus and 20 strains of methicillin resistant S aureus were studied. All were isolated from community acquired respiratory infections during 1999. Minimal inhibitory concentrations of moxifloxacin, amoxicillin, amoxicillin/clavulanic acid, clarithromycin, azithromycin, ciprofloxacin and levofloxacin were determined using the Etest method. Beta-lactamase production by H influenzae and M catarrhalis was also studied.

RESULTS:

S pneumoniae strains were 100% susceptible to quinolones and cotrimoxazole, 2% were resistant to macrolides, 11% were resistant to amoxicillin/clavulanic acid and 47% were resistant to cefuroxime. H influenzae was 100% susceptible to quinolones, azithromycin and amoxicillin/clavulanic acid. There was a 53% resistance to cotrimoxazole, 21% to amoxicillin, 9% to clarithromycin and 7% to cefuroxime. M catarrahalis was 100% susceptible to quinolones and 100% resistant to amoxicillin, 5% resistant to macrolides, 14% resistant to amoxicillin/clavulanic acid, 20% to cefuroxime and 30% to cotrimoxazole. Methicillin susceptible S aureus was susceptible to all antimicrobials and methicillin resistant S aureus was resistant to all.

CONCLUSIONS:

Maxifloxacin and the new respiratory quinolones can be useful in the treatment of respiratory infections.

• Authors: V Prado, M Giangrieco, C Durán, A Ojeda, R van Flaskamp
• Journal: Revista medica de Chile (Rev Med Chil) Vol. 128 Issue 12 Pg. 1319-26 (Dec 2000) ISSN: 0034-9887 [Print] Chile
• Vernacular Title: Actividad comparativa in vitro de moxifloxacina y otros antimicrobianos frente a patógenos respiratorios.
• PMID: 11227240 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Anti-Bacterial Agents
• Anti-Infective Agents
• Fluoroquinolones
• Lactams
• Macrolides

Topics

• Adult
• Anti-Bacterial Agents (pharmacology)
• Anti-Infective Agents (pharmacology)
• Drug Resistance, Microbial
• Female
• Fluoroquinolones
• Haemophilus influenzae (drug effects)
• Humans
• Lactams
• Macrolides
• Male
• Microbial Sensitivity Tests
• Moraxella catarrhalis (drug effects)
• Respiratory Tract Infections (drug therapy, microbiology)
• Staphylococcus aureus (drug effects)
• Streptococcus pneumoniae (drug effects)