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Raised interleukin-6 levels in obese patients.

AbstractOBJECTIVE:
Obese patients demonstrate a variety of biochemical, metabolic, and pulmonary abnormalities. Inflammatory mediators such as tumor necrosis factor-alpha and interleukin-6 (IL-6) may have a direct effect on glucose and lipid metabolism. Hypoxemia in itself induces release of IL-6. The aim of this study was to examine the relationship between IL-6 levels in healthy volunteers (control group) and three different groups of obese patients: patients without obstructive sleep apnea syndrome (OSAS), patients with OSAS, and patients with obesity hypoventilation syndrome (OHS) (daytime baseline oxygen saturation of <93%).
RESEARCH METHODS AND PROCEDURES:
We measured serum IL-6 levels in 25 obese patients (body mass index of >35 kg/m2) and 12 healthy women.
RESULTS:
The results demonstrate statistically significant differences in serum IL-6 levels between the control group (1.28 +/- 0.85 pg/mL) and obese patients without OSAS (7.69 +/- 5.06 pg/mL, p < 0.05) and with OSAS (5.58 +/- 0.37 pg/mL, p < 0.0005). In the patients with OHS, IL-6 concentrations were highest (43.13 +/- 24.27 pg/mL).
DISCUSSION:
We conclude that serum IL-6 is increased in obese patients. The highest IL-6 levels were found in the patients with OHS.
AuthorsL Roytblat, M Rachinsky, A Fisher, L Greemberg, Y Shapira, A Douvdevani, S Gelman
JournalObesity research (Obes Res) Vol. 8 Issue 9 Pg. 673-5 (Dec 2000) ISSN: 1071-7323 [Print] United States
PMID11225716 (Publication Type: Clinical Trial, Comparative Study, Controlled Clinical Trial, Journal Article)
Chemical References
  • Interleukin-6
Topics
  • Adult
  • Female
  • Humans
  • Hypoventilation (blood, complications)
  • Interleukin-6 (blood)
  • Male
  • Middle Aged
  • Obesity (blood, complications, physiopathology)
  • Oxygen Consumption (physiology)
  • Sleep Apnea, Obstructive (blood, complications)
  • Syndrome

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