Translocation 4p-- syndrome: a general review.

Abstract

The casee presented here may be the first fully identified and verified cas of translocation 4p-- syndrome, a B4/G22 translocation, ie, 45,XX,-4,-22,+t(4q 22q). Thirty-nine other cases of the 4p--syndrome, including one other possible translocation case, have been found in the medical literature. Conventional chromosome studies cannot distinguish between 4p-- (Wolf) syndrome and 5p-- (cri-du-chat) syndrome, and the clinical features, as in our case, may not be sufficiently characteristic to permit differentiation. The newer chromosome banding techniques have made specific identification possible.

• Authors: W R Centerwall, W P Thompson, I E Allen, C D Fobes
• Journal: American journal of diseases of children (1960) (Am J Dis Child) Vol. 129 Issue 3 Pg. 366-70 (Mar 1975) ISSN: 0002-922X [Print] United States
• PMID: 1121968 (Publication Type: Case Reports, Journal Article, Research Support, U.S. Gov't, Non-P.H.S.)

Topics

• Abnormalities, Multiple
• Child, Preschool
• Chromosome Aberrations (diagnosis)
• Chromosome Disorders
• Chromosomes, Human, 4-5
• Cri-du-Chat Syndrome (diagnosis)
• Dermatoglyphics
• Diagnosis, Differential
• Female
• Follow-Up Studies
• Humans
• Karyotyping (methods)
• Syndrome
• Translocation, Genetic