Abstract | OBJECTIVE: DESIGN: Multicentre, double-blind, randomised, placebo-controlled trial. SETTING: Inpatient gynaecology wards in eight collaborating centres. POPULATION: Twenty-five women with severe hyperemesis of which 24 completed the one- week study period. METHODS: MAIN OUTCOME MEASURES: Frequency of vomiting and the dependence on intravenous fluid replacement therapy after one week of treatment. RESULTS: There was a non-significant trend towards improved nausea and vomiting and reduced dependence on intravenous fluids. However, steroid therapy led to an improved sense of wellbeing (P = 0.021), improved appetite (P = 0.039) and increased weight gain (P = 0.025) compared with placebo. There was no difference in pregnancy outcome between the treatment and placebo groups. CONCLUSIONS: This study supports a beneficial role for steroids in severe hyperemesis, but did not validate the hypothesis that they lead to rapid and complete remission of symptoms. The study was not large enough to demonstrate a significant improvement in the primary outcome measures.
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Authors | C Nelson-Piercy, P Fayers, M de Swiet |
Journal | BJOG : an international journal of obstetrics and gynaecology
(BJOG)
Vol. 108
Issue 1
Pg. 9-15
(Jan 2001)
ISSN: 1470-0328 [Print] England |
PMID | 11213010
(Publication Type: Clinical Trial, Journal Article, Multicenter Study, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Chemical References |
- Blood Glucose
- Glucocorticoids
- Prednisolone
|
Topics |
- Administration, Oral
- Blood Glucose
(metabolism)
- Double-Blind Method
- Female
- Glucocorticoids
(therapeutic use)
- Humans
- Hyperemesis Gravidarum
(drug therapy)
- Prednisolone
(therapeutic use)
- Pregnancy
- Surveys and Questionnaires
- Treatment Outcome
|