Abstract | BACKGROUND: Previous experiments have demonstrated that acute exposure to a high- cholesterol diet (HCD) increases the severity of myocardial infarction in animals. Recent results suggest that the process is modulated by multiple genes and their interactions with circulating cholesterol. DESIGN: METHODS: RESULTS: The extent of infarction (percentage infarct/area at risk) was significantly less (P < 0.05) after 1 week of a HCD (18.7 +/- 7.0%) than those for the normal diet group (51.4 +/- 5.5%) and the group fed a HCD for 6 weeks (44.4 +/- 5.2%). Additionally, there was significantly less infiltration of neutrophils into the ischemic-reperfused mouse hearts for mice fed a HCD for 1 week. Levels of reduced and oxidized glutathione in the hearts of CETP mice were measured for separate groups of animals. The reduced: oxidized-glutathione ratio was significantly (P < 0.01) lower for mice fed a HCD for 1 week (1.5 +/- 0.1) than it was for mice fed a normal diet (3.6 +/- 0.3) and a HCD for 6 weeks (3.3 +/- 0.2). CONCLUSIONS: These data suggest that activity of CETP in hypercholesterolemic mice has an acute effect on size of infarct after 1 week of a HCD. This suggests that CETP induces tolerance of ischemia in the mice fed a HCD via mild oxidative stress.
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Authors | S P Jones, W G Girod, K R Marotti, T Y Aw, D J Lefer |
Journal | Coronary artery disease
(Coron Artery Dis)
Vol. 12
Issue 1
Pg. 37-44
(Feb 2001)
ISSN: 0954-6928 [Print] England |
PMID | 11211164
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)
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Chemical References |
- Carrier Proteins
- Cholesterol Ester Transfer Proteins
- Cholesterol, Dietary
- Glycoproteins
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Topics |
- Animals
- Carrier Proteins
(physiology)
- Cholesterol Ester Transfer Proteins
- Cholesterol, Dietary
(administration & dosage)
- Glycoproteins
(physiology)
- Hemodynamics
- Hypercholesterolemia
(physiopathology)
- Male
- Mice
- Mice, Transgenic
- Myocardial Infarction
(physiopathology)
- Myocardial Reperfusion Injury
(physiopathology)
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