HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Choosing an oestrogen replacement therapy in young adult women with Turner syndrome.

AbstractOBJECTIVE:
Hormone replacement therapy (HRT) is prescribed to most patients with Turner syndrome (TS) although its use in adult TS patients has not been scientifically evaluated. The present study was performed to compare the short-term effects in adult women with Turner syndrome of low-dose oral conjugated oestrogen (0.625 mg, CE) with relatively high dose ethinyl oestradiol (30 microg, EE2); both combined with an oral progestin.
DESIGN AND PATIENTS:
After 4 months off HRT, 17 young, otherwise healthy women with TS were enrolled in a random, unblinded, crossover study of the two oestrogenic preparations, each given for 6 months.
MEASUREMENTS:
We compared parameters of oestrogenic activity that would cover immediate changes in hormone levels, biochemistry, bone turnover, uterine and cardiac variables, which constitute risk factors for later development of diabetes, atherosclerosis, osteoporosis and aortic dissection.
RESULTS:
Serum FSH returned to normal follicular phase levels only on the EE2 regimen. The hypotrophic endometria normalized with either of the two oestrogen regimens with no excessive hypertrophy. Hyperinsulinaemia was suppressed to normal by both EE2 and CE. PTH and 1,25-dihydroxyvitamin D levels increased on HRT (EE2 > CE), and phosphorus decreased. Alkaline phosphatase, osteocalcin and urinary deoxypyridinoline cross-links (DPD) were high off therapy; the former two suppressed to high-normal levels on the EE2 regimen, but not on CE, and DPD did not normalize with either HRT. Lipid profiles in these young TS patients were normal. Liver enzymes were mildly elevated off therapy and suppressed to normal levels on both regimens, but more so with EE2.
CONCLUSIONS:
The risk factors embodied in hyperinsulinaemia and enhanced bone turnover which, ultimately, have consequences for TS morbidity, are minimized by HRT. In the short term, neither regimen is effective for bone turnover in adult women with Turner syndrome.
AuthorsH Guttmann, Z Weiner, E Nikolski, S Ish-Shalom, J Itskovitz-Eldor, M Aviram, S Reisner, Z Hochberg
JournalClinical endocrinology (Clin Endocrinol (Oxf)) Vol. 54 Issue 2 Pg. 159-64 (Feb 2001) ISSN: 0300-0664 [Print] England
PMID11207629 (Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial)
Chemical References
  • Amino Acids
  • Biomarkers
  • Estrogens, Conjugated (USP)
  • Progestins
  • Osteocalcin
  • Ethinyl Estradiol
  • deoxypyridinoline
Topics
  • Adolescent
  • Adult
  • Amino Acids (urine)
  • Aortic Aneurysm (complications)
  • Biomarkers (blood, urine)
  • Bone Remodeling (drug effects)
  • Cross-Over Studies
  • Drug Administration Schedule
  • Echocardiography
  • Endometrium (drug effects)
  • Estrogen Replacement Therapy
  • Estrogens, Conjugated (USP) (administration & dosage)
  • Ethinyl Estradiol (administration & dosage)
  • Female
  • Humans
  • Liver Function Tests
  • Osteocalcin (blood)
  • Progestins (therapeutic use)
  • Turner Syndrome (complications, drug therapy, metabolism)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: