Abstract | BACKGROUND: PATIENTS AND METHODS: RESULTS: The eradication rates of the 5-day RACM regimen and the 7-day RAC regimen were 93% (95% CI: 84--97%) and 81% (95% CI: 71--89%) by intention-to-treat analysis, 94% (95% CI: 86--98%) and 83% (95% CI: 73--91%) by all-patients-treated analysis analysis and 95% (95% CI: 87--98%; P < 0.05) and 82% (95% CI: 72--90%) by per protocol analysis, respectively. No serious adverse effect was observed, and 99% of the patients reported complete compliance. CONCLUSIONS: The cure rate of the 5-day RACM regimen was more effective than the 7-day RAC regimen, suggesting that this regimen could be preferable as a first-line therapy for H. pylori infection.
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Authors | A Nagahara, H Miwa, T Yamada, A Kurosawa, R Ohkura, N Sato |
Journal | Alimentary pharmacology & therapeutics
(Aliment Pharmacol Ther)
Vol. 15
Issue 3
Pg. 417-21
(Mar 2001)
ISSN: 0269-2813 [Print] England |
PMID | 11207518
(Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial)
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Chemical References |
- 2-Pyridinylmethylsulfinylbenzimidazoles
- Anti-Bacterial Agents
- Anti-Infective Agents
- Anti-Ulcer Agents
- Benzimidazoles
- Carbon Isotopes
- Penicillins
- Metronidazole
- Rabeprazole
- Amoxicillin
- Clarithromycin
- Omeprazole
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Topics |
- 2-Pyridinylmethylsulfinylbenzimidazoles
- Administration, Oral
- Adolescent
- Adult
- Aged
- Amoxicillin
(administration & dosage, pharmacology)
- Anti-Bacterial Agents
(administration & dosage, pharmacology)
- Anti-Infective Agents
(administration & dosage, pharmacology)
- Anti-Ulcer Agents
(administration & dosage, pharmacology)
- Benzimidazoles
(administration & dosage, pharmacology)
- Breath Tests
- Carbon Isotopes
- Clarithromycin
(administration & dosage, pharmacology)
- Drug Administration Schedule
- Drug Therapy, Combination
- Female
- Helicobacter Infections
(drug therapy, pathology)
- Humans
- Male
- Metronidazole
(administration & dosage, pharmacology)
- Middle Aged
- Omeprazole
(analogs & derivatives)
- Penicillins
(administration & dosage, pharmacology)
- Rabeprazole
- Treatment Outcome
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