Inhibitory effect of dietary inulin or oligofructose on the development of cancer metastases.

Abstract

The possible influence of continuous dietary treatment with 15% inulin or oligofructose on the development of lung metastases of a transplantable liver tumor in young male C3H mice was investigated. Microscopical examination demonstrated a distinct inhibitory effect of this dietary treatment on the development of lung metastases of this tumor. There were 59% of mice bearing lung metastases in the control group, 36% in the inulin fed group and 35% in the oligofructose fed group. The total number of lung metastases was 37 in the control group, 18 in inulin fed and 6 in oligofructose fed mice. Several possible, mechanisms hypothetically involved in this astonishing inhibition of the development of lung metastases by dietary treatment with inulin or oligofructose are discussed.

• Authors: H S Taper, M B Roberfroid
• Journal: Anticancer research (Anticancer Res) 2000 Nov-Dec Vol. 20 Issue 6B Pg. 4291-4 ISSN: 0250-7005 [Print] Greece
• PMID: 11205260 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Oligosaccharides
• oligofructose
• Inulin

Topics

• Animals
• Drug Screening Assays, Antitumor
• Inulin (administration & dosage, pharmacology)
• Liver Neoplasms (pathology)
• Lung Neoplasms (prevention & control, secondary)
• Male
• Mice
• Mice, Inbred C3H
• Neoplasm Transplantation
• Oligosaccharides (administration & dosage, pharmacology)