Abstract | AIMS: METHODS: 45 patients, aged 21 to 84 years, presenting with an effusion of the knee, related to degenerative or inflammatory joint disease, were included in this study after having given their written consent. One blood and one SF sample were drawn concomitantly in each patient from 0.5 to 48 h after NSAID administration. Piroxicam assays were performed by high performance liquid chromatography. Pharmacokinetic parameters were obtained from the mean plasma and synovial concentrations measured at various sampling times. RESULTS: The peak concentration was higher in plasma (2.51+/-0.25 microg/ml) than in SF (1.31+/-0.76 microg/ml), but the elimination half-life was much longer in SF (90.7 h) than in plasma (32.5 h). The SF/plasma area under the concentration-time curve ratio (evaluating the quantity of NSAID transferred from the blood to the joint) was equal to 0.39. CONCLUSIONS:
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Authors | B Bannwart, P Bertin, F Péhourcq, T Schaeverbeke, P Gillet, G Lefrançois, R Trèves, J Dehais, P Netter, A Gaucher |
Journal | International journal of clinical pharmacology and therapeutics
(Int J Clin Pharmacol Ther)
Vol. 39
Issue 1
Pg. 33-6
(Jan 2001)
ISSN: 0946-1965 [Print] Germany |
PMID | 11204935
(Publication Type: Clinical Trial, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Anti-Inflammatory Agents, Non-Steroidal
- Cyclodextrins
- Drug Combinations
- beta-Cyclodextrins
- Piroxicam
- piroxicam-beta-cyclodextrin
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Topics |
- Administration, Oral
- Adult
- Aged
- Aged, 80 and over
- Anti-Inflammatory Agents, Non-Steroidal
(administration & dosage, pharmacokinetics)
- Area Under Curve
- Arthritis, Rheumatoid
(drug therapy)
- Cyclodextrins
(administration & dosage, pharmacokinetics)
- Drug Combinations
- Female
- Half-Life
- Humans
- Joint Diseases
(drug therapy)
- Knee Joint
(pathology)
- Male
- Middle Aged
- Piroxicam
(administration & dosage, blood, pharmacokinetics)
- Synovial Fluid
(chemistry)
- beta-Cyclodextrins
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