Phytochemical study and anti-inflammatory properties of Lampaya hieronymi Schum. ex Moldenke.

Abstract

The chemical study of aerial parts of Lampaya hieronymi Schum. ex Moldenke yielded oleanolic acid, epi-oleanolic acid, epi-maslinic acid, 4'7-dimethoxyapigenin, p-hydroxyacetophenone, and p-hydroxyacetophenone-beta-glucoside. In searching for natural products as potential anti-inflammatory agents, all the compounds, except 4'7-dimethoxyapigenin were evaluated in vivo for their ability to inhibit acute inflammation. Our studies demonstrated that p-hydroxyacetophenone and the triterpenes produced protective effects in carrageenan induced paw edema in mouse, at 1-3 h and 3-5 h, respectively, after the injection of carrageenan. These results indicated that their effects might correlate with the release of histamine, serotonin, kinin and prostaglandins.

• Authors: M E Alvarez, A E Rotelli, L E Pelzer, J R Saad, O Giordano
• Journal: Farmaco (Societa chimica italiana : 1989) (Farmaco) 2000 Jun-Jul Vol. 55 Issue 6-7 Pg. 502-5 ISSN: 0014-827X [Print] France
• PMID: 11204754 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Anti-Inflammatory Agents, Non-Steroidal
• Plant Extracts
• Carrageenan

Topics

• Animals
• Anti-Inflammatory Agents, Non-Steroidal (administration & dosage, isolation & purification, pharmacology)
• Carrageenan
• Edema (chemically induced, prevention & control)
• Female
• Injections, Intraperitoneal
• Male
• Mice
• Plant Extracts (administration & dosage, chemistry, pharmacology)
• Plants, Medicinal (chemistry)