Abstract |
The present study was carried out to clarify the effects of extracts of the leaves of Mentha piperita L. on experimental allergic rhinitis. The 50% EtOH extract of peppermint inhibited histamine release from rat peritoneal mast cells induced by compound 48/80. The effect was dose-dependent and significant inhibition was observed at a concentration of 3 microg/ml. In addition, the 50% EtOH eluate separated from the 50% EtOH extract of peppermint by column chromatography (DIAION HP-20) was also effective in inhibiting histamine release at a concentration of 1 microg/ml. Nasal symptoms, sneezing and nasal rubbing induced by antigen challenge in actively sensitized rats were inhibited by oral administration of the 50% EtOH eluate. Significant inhibition of sneezing and nasal rubbing was observed at doses of 300 and 1000 mg/kg, p.o., respectively. Furthermore, the 50% EtOH eluate inhibited dye leakage into the nasal cavity of rats induced by antigen in a dose-dependent manner. These results suggested that extracts of Mentha piperita L. may be clinically effective in alleviating the nasal symptoms of allergic rhinitis.
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Authors | T Inoue, Y Sugimoto, H Masuda, C Kamei |
Journal | Biological & pharmaceutical bulletin
(Biol Pharm Bull)
Vol. 24
Issue 1
Pg. 92-5
(Jan 2001)
ISSN: 0918-6158 [Print] Japan |
PMID | 11201253
(Publication Type: Journal Article)
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Chemical References |
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Topics |
- Animals
- Cells, Cultured
- Histamine Release
(drug effects)
- Male
- Mast Cells
(drug effects, metabolism)
- Mentha piperita
- Nasal Cavity
(metabolism)
- Plant Extracts
(chemistry, therapeutic use)
- Rats
- Rats, Wistar
- Rhinitis, Allergic, Perennial
(drug therapy)
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