Abstract |
Actinomycotic mycetomas usually respond slowly to treatment with antibiotics. In an attempt to hasten clinical resolution, we used a 2-step regimen consisting of an intensive phase of therapy with penicillin, gentamycin and co-trimoxazole for 5-7 weeks, followed by maintenance therapy with amoxicillin and co-trimoxazole. Seven patients were treated, all of whom showed significant reduction in discharge and swelling after the intensive phase. Maintenance therapy was continued for 2-5 months after the lesions became completely inactive. Five patients completed maintenance therapy, which was given for 6-16 months (mean 10.7 months), and remained free of disease during a mean post-treatment follow-up period of 6.4 months. The other 2 patients also responded satisfactorily and continue to receive maintenance therapy. Side-effects necessitating a modification of the treatment schedule occurred in 2 patients but reversed on discontinuation of the drugs responsible. This treatment schedule produces a rapid clinical response during the initial, intensive phase and promotes compliance with the longer maintenance phase of treatment necessary to achieve a complete cure.
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Authors | M Ramam, T Garg, P D'Souza, K K Verma, B K Khaitan, M K Singh, U Banerjee |
Journal | Acta dermato-venereologica
(Acta Derm Venereol)
Vol. 80
Issue 5
Pg. 378-80
( 2000)
ISSN: 0001-5555 [Print] Sweden |
PMID | 11200840
(Publication Type: Journal Article)
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Chemical References |
- Gentamicins
- Penicillins
- Amoxicillin
- Trimethoprim, Sulfamethoxazole Drug Combination
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Topics |
- Actinomycosis
(diagnosis, drug therapy)
- Adolescent
- Adult
- Amoxicillin
(therapeutic use)
- Drug Administration Schedule
- Drug Therapy, Combination
(therapeutic use)
- Female
- Gentamicins
(therapeutic use)
- Humans
- Long-Term Care
- Male
- Middle Aged
- Mycetoma
(diagnosis, drug therapy)
- Penicillins
(therapeutic use)
- Trimethoprim, Sulfamethoxazole Drug Combination
(therapeutic use)
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