Anticalculus efficacy of an antiseptic mouthrinse containing zinc chloride.

The authors undertook a controlled clinical study to determine the efficacy of a tartar-control antiseptic mouthrinse in inhibiting the development of supragingival dental calculus.
After undergoing a dental prophylaxis, 334 subjects with a moderate rate of calculus formation were stratified and randomly assigned to one of three groups: positive control (using a tartar-control toothpaste and an antiseptic rinse), negative control (using a regular toothpaste and an antiseptic mouthrinse) or experimental (using a regular dentifrice and a tartar-control mouthrinse). Subjects brushed and rinsed twice daily, unsupervised, for four months. The researchers assessed subjects' calculus levels using the Volpe-Manhold Index, or VMI, after 16 weeks.
Using analysis of covariance, the authors found that both the experimental group (which used a tartar-control rinse containing zinc chloride) and the positive control group (which used a tartar-control dentifrice containing pyrophosphate) demonstrated statistically significantly lower VMI scores (P = .001) than the negative control group (which used a regular dentifrice and an antiseptic rinse). Both anticalculus agents provided a clinically relevant 21 percent reduction in calculus formation.
An antiseptic mouthrinse containing 0.09 percent zinc chloride as the anticalculus agent provides a clinically relevant reduction in calculus formation in people with a moderate rate of such formation.
A tartar-control mouthrinse with zinc chloride as the tartar-control ingredient is clinically effective in reducing the formation of calculus.
AuthorsC H Charles, M J Cronin, N J Conforti, W Z Dembling, D M Petrone, J A McGuire
JournalJournal of the American Dental Association (1939) (J Am Dent Assoc) Vol. 132 Issue 1 Pg. 94-8 (Jan 2001) ISSN: 0002-8177 [Print] United States
PMID11194406 (Publication Type: Clinical Trial, Journal Article, Multicenter Study, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
Chemical References
  • Chlorides
  • Drug Combinations
  • Mouthwashes
  • Organic Chemicals
  • Salicylates
  • Terpenes
  • Zinc Compounds
  • tartar control listerine
  • Listerine
  • zinc chloride
  • Adolescent
  • Adult
  • Aged
  • Analysis of Variance
  • Chi-Square Distribution
  • Chlorides (therapeutic use)
  • Dental Calculus (prevention & control)
  • Double-Blind Method
  • Drug Combinations
  • Female
  • Humans
  • Male
  • Middle Aged
  • Mouthwashes (therapeutic use)
  • Odds Ratio
  • Oral Hygiene Index
  • Organic Chemicals
  • Salicylates (therapeutic use)
  • Terpenes (therapeutic use)
  • Treatment Outcome
  • Zinc Compounds (therapeutic use)

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