Abstract | OBJECTIVE: To investigate the endocrinological and endometrial factors in women with unexplained recurrent miscarriage
DESIGN: Prospective, case study SETTING: PARTICIPANTS: One hundred and forty-four women with unexplained recurrent (> or =3) miscarriages
METHODS: A blood sample was obtained in early follicular phase (day 3-5) to measure follicle stimulating hormone, luteinising hormone, prolactin, androgens and thyroid function; daily blood/urine samples were obtained from mid-follicular phase to measure luteinising hormone until the luteinising hormone surge was identified; endometrial biopsy and a further blood sample for progesterone measurement were obtained in the mid-luteal phase. A transvaginal ultrasonography was performed to evaluate ovarian morphology. RESULTS: Hypersecretion of luteinising hormone or ultrasonographic features of polycystic ovarian disease was present in 8% and 7.8% of women, respectively. The free androgen index was elevated in 14.6% of subjects. In the mid-luteal phase, low progesterone level was found in 17.4% and delayed endometrial development was noted in 27.1% of women. Although women with recurrent miscarriage women and delayed endometrium had significantly lower progesterone levels than those with normal endometrial development, only 8/24 had mid-luteal progesterone levels below 30 nmol/L. Recurrent miscarriage was not associated with hyperprolactinaemia or abnormal thyroid function test. CONCLUSIONS: Endocrinological and endometrial abnormalities are present in about a quarter of women with unexplained recurrent miscarriage.
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Authors | T C Li, M D Spuijbroek, E Tuckerman, B Anstie, M Loxley, S Laird |
Journal | BJOG : an international journal of obstetrics and gynaecology
(BJOG)
Vol. 107
Issue 12
Pg. 1471-9
(Dec 2000)
ISSN: 1470-0328 [Print] England |
PMID | 11192102
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Sex Hormone-Binding Globulin
- Testosterone
- Androstenedione
- Progesterone
- Estradiol
- Prolactin
- Luteinizing Hormone
- Follicle Stimulating Hormone
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Topics |
- Abortion, Habitual
(blood, etiology)
- Adult
- Androstenedione
(blood)
- Endocrine System Diseases
(blood, complications)
- Endometrium
- Estradiol
(blood)
- Female
- Follicle Stimulating Hormone
(blood)
- Humans
- Luteinizing Hormone
(blood, urine)
- Pregnancy
- Progesterone
(blood)
- Prolactin
(blood)
- Prospective Studies
- Sex Hormone-Binding Globulin
(metabolism)
- Testosterone
(blood)
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