[Homeostatic and antioxidant defense enzymes activity in chronic pyelonephritis].

Abstract

As shown by the analysis of chronic pyelonephritis, manifestations in patients with high and low activity of antioxidant system enzymes, patients with high catalase activity have more effective defense of red cells, glomerular epithelium. This was concluded from marked differences in urinary excretion of metabolites, hemoglobin levels compared to those in patients with low activity of catalase. In low activity of glutathione peroxidase, inflammation gains activity, nonspecific resistance weakens, excretion of some metabolites inhibits vs patients with high activity of this enzyme. The data provide criteria for diagnosis of antioxidant system defects and show necessity of antioxidant drugs inclusion into the therapeutic scheme (unitiol, antioxidant complex of vitamins A, E, C, P).

• Authors: V E Tsvettskikh, B A Berdichevskiĭ, V R Sultanbaev, N I Kazeko, A A Ovshinnikov, A V Murychev, I V Tsvettskikh, Iu M Molokov
• Journal: Urologiia (Moscow, Russia : 1999) (Urologiia) 2000 May-Jun Issue 3 Pg. 13-5 ISSN: 1728-2985 [Print] Russia (Federation)
• Vernacular Title: Pokazateli gomeostaza i funktsional'noe sostoianie fermentov antioksidantnoĭ zashchity pri khronicheskom pielonefrite.
• PMID: 11186700 (Publication Type: Comparative Study, English Abstract, Journal Article)

Chemical References

• Antioxidants
• Biomarkers
• Catalase
• Glutathione Peroxidase

Topics

• Adolescent
• Adult
• Antioxidants (metabolism)
• Biomarkers
• Catalase (metabolism)
• Chronic Disease
• Disease Progression
• Erythrocyte Membrane (metabolism)
• Female
• Glutathione Peroxidase (metabolism)
• Homeostasis
• Humans
• Kidney Glomerulus (enzymology)
• Male
• Middle Aged
• Oxidative Stress
• Pyelonephritis (enzymology)