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Effect of 3 mg melatonin on jet lag syndrome in an 8-h eastward flight.

Abstract
In order to assess the effect of melatonin on jet lag a field study was undertaken. The process of re-entrainment of circadian melatonin rhythm was investigated in six subjects. Except during 24-h blood sampling, the subjects were exposed to natural zeitgeber (time giver) outdoors and given 3 mg melatonin at 23:00 h. The subjects were exposed to bright sunlight from 3000 to 12000 lx. All of them showed orthodromic re-entrainment with taking melatonin, while two out of the six did not show orthodromic re-entrainment without taking melatonin. Melatonin accelerated the rate of the re-entrainment of the circadian melatonin rhythm. Melatonin was useful to jet travel from Tokyo to Los Angeles.
AuthorsT Takahashi, M Sasaki, H Itoh, M Ozone, W Yamadera, K Hayshida, S Ushijima, N Matsunaga, K Obuchi, H Sano
JournalPsychiatry and clinical neurosciences (Psychiatry Clin Neurosci) Vol. 54 Issue 3 Pg. 377-8 (Jun 2000) ISSN: 1323-1316 [Print] Australia
PMID11186121 (Publication Type: Journal Article)
Chemical References
  • Melatonin
Topics
  • Adult
  • Circadian Rhythm (drug effects)
  • Humans
  • Jet Lag Syndrome (blood, drug therapy)
  • Melatonin (administration & dosage, blood)
  • Middle Aged
  • Polysomnography
  • Sleep Stages (drug effects)

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