Abstract |
In order to assess the effect of melatonin on jet lag a field study was undertaken. The process of re-entrainment of circadian melatonin rhythm was investigated in six subjects. Except during 24-h blood sampling, the subjects were exposed to natural zeitgeber (time giver) outdoors and given 3 mg melatonin at 23:00 h. The subjects were exposed to bright sunlight from 3000 to 12000 lx. All of them showed orthodromic re-entrainment with taking melatonin, while two out of the six did not show orthodromic re-entrainment without taking melatonin. Melatonin accelerated the rate of the re-entrainment of the circadian melatonin rhythm. Melatonin was useful to jet travel from Tokyo to Los Angeles.
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Authors | T Takahashi, M Sasaki, H Itoh, M Ozone, W Yamadera, K Hayshida, S Ushijima, N Matsunaga, K Obuchi, H Sano |
Journal | Psychiatry and clinical neurosciences
(Psychiatry Clin Neurosci)
Vol. 54
Issue 3
Pg. 377-8
(Jun 2000)
ISSN: 1323-1316 [Print] Australia |
PMID | 11186121
(Publication Type: Journal Article)
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Chemical References |
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Topics |
- Adult
- Circadian Rhythm
(drug effects)
- Humans
- Jet Lag Syndrome
(blood, drug therapy)
- Melatonin
(administration & dosage, blood)
- Middle Aged
- Polysomnography
- Sleep Stages
(drug effects)
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