Abstract | BACKGROUND: METHODS: Seven patients (5 females and 2 males) with a diagnosis of cystic lesion of the pancreas were observed after 1995. Clinical, radiological, and pathologic features, including immunohistochemistry, were reported. Enzymes and tumor markers CEA, CA 19-9, CA 125, CA 15-3, CA 72-4, and mucin-like carcinoma-associated antigen (MCA) were investigated in the serum and cyst fluid of the patients. Cytology was also performed. RESULTS: Six patients were symptomatic complaining abdominal pain. All cases had radiologic evidence of unilocular cyst of the pancreas. The suspected diagnosis was consistent with mucinous cystic neoplasm. Serum tumor markers were all in the normal range. After surgery, pathology showed in all cases a cyst lined with cuboidal, periodic acid-Schiff (PAS)-positive epithelium, without mucin content or atypia. Minute microcysts were found surrounding the main cavity. Immunohistochemical stains were positive for cytokeratin, CA19-9, CA15-3, CA 72-4, and MCA. CEA was unexpressed. CA 125 in the cyst fluid were found elevated in three cases and CA 19-9 in three cases. Cytology was negative in all cases. CONCLUSION:
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Authors | C Sperti, C Pasquali, A Perasole, G Liessi, S Pedrazzoli |
Journal | International journal of pancreatology : official journal of the International Association of Pancreatology
(Int J Pancreatol)
Vol. 28
Issue 1
Pg. 1-7
(Aug 2000)
ISSN: 0169-4197 [Print] United States |
PMID | 11185705
(Publication Type: Case Reports, Journal Article)
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Chemical References |
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Topics |
- Adult
- Aged
- Biomarkers, Tumor
(metabolism)
- Cyst Fluid
(chemistry)
- Cystadenoma, Serous
(diagnosis, metabolism, pathology)
- Diagnosis, Differential
- Female
- Humans
- Immunohistochemistry
- Male
- Middle Aged
- Pancreas
(metabolism, pathology)
- Pancreatic Neoplasms
(diagnosis, metabolism, pathology)
- Tomography, X-Ray Computed
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