NdWFamide: a novel excitatory peptide involved in cardiovascular regulation of Aplysia.

Although diverse peptides are known to affect invertebrate cardiac activity, the peptidergic regulation of the cardiovascular system of Aplysia is still poorly understood. Asn-D-Trp-Phe-NH(2) (NdWFamide) is a recently purified cardioactive peptide in Aplysia. Pharmacological experiments showed that NdWFamide was one of the most potent cardioexcitatory peptides among the known endogenous cardioactive peptides in Aplysia. NdWFamide-immunopositive neuronal processes were abundant in the cardiovascular region of Aplysia, and many of them originated from neurosecretory cells in the abdominal ganglion (R3-R13 cells). The data suggest that NdWFamide is a cardioexcitatory peptide utilized by R3-R13 cells of Aplysia.
AuthorsF Morishita, K Sasaki, K Kanemaru, Y Nakanishi, O Matsushima, Y Furukawa
JournalPeptides (Peptides) Vol. 22 Issue 2 Pg. 183-9 (Feb 2001) ISSN: 0196-9781 [Print] United States
PMID11179811 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Oligopeptides
  • asparaginyl-tryptophyl-phenylalaninamide
  • Animals
  • Aplysia (physiology)
  • Cardiovascular System (innervation, metabolism)
  • Ganglia (physiology)
  • Immunohistochemistry
  • Oligopeptides (metabolism)

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