Activation of mu-opiate receptors as a factor of regulation of heart resistance to ischemia-reperfusion and oxidative stress.

Abstract

Intravenous injection of the selective mu-opiate receptor agonist DAMGO (0.1 mg/kg, 15 min before isolation of the heart) improved resistance of isolated perfused rat heart to ischemia (45 min) and reperfusion (60 min) damages. In vivo administration of DAMGO prevented reperfusion-induced damages to cardiomyocytes and decreased the content of conjugated dienes in the myocardium during ischemia-reperfusion in vitro. Furthermore, stimulation of mu-opiate receptors promoted recovery of myocardial contractility during reoxygenation, but had no effect on heart resistance to free radical-induced damages during perfusion of isolated heart with a solution containing Fe2+ and ascorbic acid.

• Authors: T V Lasukova, T Y Rebrova, S V Tam
• Journal: Bulletin of experimental biology and medicine (Bull Exp Biol Med) Vol. 130 Issue 8 Pg. 752-5 (Aug 2000) ISSN: 0007-4888 [Print] United States
• PMID: 11177234 (Publication Type: Journal Article)

Chemical References

• Receptors, Opioid, mu
• Enkephalin, Ala(2)-MePhe(4)-Gly(5)-

Topics

• Animals
• Enkephalin, Ala(2)-MePhe(4)-Gly(5)- (pharmacology)
• In Vitro Techniques
• Male
• Myocardial Contraction (drug effects, physiology)
• Myocardial Reperfusion Injury (etiology, physiopathology, prevention & control)
• Oxidative Stress
• Rats
• Rats, Wistar
• Receptors, Opioid, mu (agonists, physiology)