Abstract | BACKGROUND: METHODS: In this study, the possible changes in GABAergic and glycinergic inhibitory activity in the spinal nerve ligation model of neuropathic pain were studied by comparing the effects of the GABAA-receptor antagonist bicuculline and the glycine-receptor antagonist strychnine in neuropathic rats to their effects in sham-operated and nonoperated control rats. RESULTS:
Bicuculline produced a dose-related facilitation of the Adelta-fiber-evoked activity in all study groups and increased C-fiber-mediated activity in the spinal nerve ligation group but not in either of the control groups. There were no differences in the effect of bicuculline on low threshold responses between the study groups. The glycine receptor antagonist strychnine did not have a statistically significant effect on any of the parameters studied in any of the control groups. CONCLUSIONS: These results support the idea of an increased GABAergic inhibitory tone in the spinal cord of neuropathic rats, possibly as compensation for increased excitability after nerve injury.
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Authors | V K Kontinen, L C Stanfa, A Basu, A H Dickenson |
Journal | Anesthesiology
(Anesthesiology)
Vol. 94
Issue 2
Pg. 333-9
(Feb 2001)
ISSN: 0003-3022 [Print] United States |
PMID | 11176099
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- gamma-Aminobutyric Acid
- Strychnine
- Glycine
- Bicuculline
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Topics |
- Animals
- Bicuculline
(pharmacology)
- Cold Temperature
- Dose-Response Relationship, Drug
- Glycine
(physiology)
- Male
- Nerve Fibers, Myelinated
(physiology)
- Pain
(physiopathology)
- Rats
- Rats, Sprague-Dawley
- Spinal Cord
(physiology)
- Strychnine
(pharmacology)
- gamma-Aminobutyric Acid
(physiology)
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