Treatment of T-prolymphocytic leukemia with nonmyeloablative allogeneic stem cell transplantation.

Abstract

AIM:

T-prolymphocytic leukemia (T-PLL) is a rare disease of the elderly characterized by a high white blood cell count and organomegaly, and is currently incurable. Our aim was to elicit graft-versus-leukemia reactions in a patient with T-PLL.

METHODS:

A 52-yr-old woman with refractory T-PLL underwent a nonmyeloablative regimen followed by allogeneic peripheral blood stem cell transplantation (a "minitransplant") from her HLA-matched sibling.

RESULTS:

There was no treatment related toxicity other than neutropenia. Engraftment was successful. The patient experienced no graft-versus-host disease (GVHD) at any time but, on day 84 after transplantation, had a relapse in the central nervous system. Despite infusion of donor lymphocytes and intralumbar chemotherapy, she died on day 157 of systemic disease.

CONCLUSION:

The reasons why treatment may have failed are discussed (nature of disease, disease progression, treatment schedule).

• Authors: L Garderet, H Bittencourt, A Kaliski, M Daniel, P Ribaud, G Socié, E Gluckman
• Journal: European journal of haematology (Eur J Haematol) Vol. 66 Issue 2 Pg. 137-9 (Feb 2001) ISSN: 0902-4441 [Print] England
• PMID: 11168523 (Publication Type: Case Reports, Journal Article)

Topics

• Facial Nerve Diseases (etiology)
• Fatal Outcome
• Female
• Graft Survival
• Graft vs Leukemia Effect
• Hematopoietic Stem Cell Transplantation
• Histocompatibility Testing
• Humans
• Leukemia, Prolymphocytic (therapy)
• Leukemia, T-Cell (therapy)
• Meningitis (etiology)
• Middle Aged
• Nuclear Family
• Recurrence
• Transplantation, Homologous