Abstract | BACKGROUND: OBJECTIVES: To assess whether BP patients have autoantibodies targeting plectin, another hemidesmosomal component showing extensive homology to BP230. METHODS: Examination of sera from 16 patients with BP, using immunoprecipitation studies followed by immunoblotting. RESULTS: Serum of one of the 16 (6%) patients with BP contain autoantibodies binding to plectin, while no reactivity was found with sera from three control subjects. Sera from all 16 BP patients immunoprecipitated BP230 from extracts of biosynthetically radiolabelled human keratinocytes. CONCLUSIONS:
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Authors | E Laffitte, B Favre, L Fontao, S Riou, F Jaunin, K Tamm, J H Saurat, L Borradori |
Journal | The British journal of dermatology
(Br J Dermatol)
Vol. 144
Issue 1
Pg. 136-8
(Jan 2001)
ISSN: 0007-0963 [Print] England |
PMID | 11167694
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Autoantibodies
- Autoantigens
- Carrier Proteins
- Cytoskeletal Proteins
- DST protein, human
- Dystonin
- Intermediate Filament Proteins
- Nerve Tissue Proteins
- Non-Fibrillar Collagens
- PLEC protein, human
- Plectin
- collagen type XVII
- Collagen
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Topics |
- Autoantibodies
(blood)
- Autoantigens
(immunology)
- Autoimmune Diseases
(immunology)
- Carrier Proteins
- Collagen
(immunology)
- Cytoskeletal Proteins
- Dystonin
- Humans
- Immunoblotting
- Intermediate Filament Proteins
(immunology)
- Nerve Tissue Proteins
- Non-Fibrillar Collagens
- Pemphigoid, Bullous
(immunology)
- Plectin
- Radioimmunoprecipitation Assay
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