The extended haplotype of the microtubule associated protein tau gene is not associated with Pick's disease.

Abstract

Pick's disease (PiD) is a rare neurodegenerative condition and is a member of a heterogeneous group of disorders known as tauopathies, so-called because of the predominantly neuronal aberrant tau accumulations found in these diseases. The tauopathy, familial frontotemporal dementia (FTD), is caused by mutations in the tau gene. Moreover, progressive supranuclear palsy (PSP) is associated with the tau H1 haplotype. In certain familial forms of FTD and in PSP the microtubule-binding four repeat tau isoform principally accumulates in neuropathological lesions. However, in PiD three repeat tau accumulations are found. We therefore investigated whether either the tau H1 or H2 haplotype was associated with PiD. Our results indicate a slight increase in H2H2 frequency in Pick's cases which is not statistically significant.

• Authors: C Russ, S Lovestone, M Baker, S M Pickering-Brown, P M Andersen, R Furlong, D Mann, J F Powell
• Journal: Neuroscience letters (Neurosci Lett) Vol. 299 Issue 1-2 Pg. 156-8 (Feb 16 2001) ISSN: 0304-3940 [Print] Ireland
• PMID: 11166961 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• tau Proteins

Topics

• Aged
• Brain (pathology)
• DNA Mutational Analysis
• Gene Frequency (genetics)
• Haplotypes (genetics)
• Humans
• Pick Disease of the Brain (genetics, pathology)
• Polymorphism, Genetic (genetics)
• Risk Factors
• tau Proteins (genetics)