Abstract |
Three parapoxviruses which cause orf or related diseases in humans and animals and the orthopoxvirus, vaccinia virus, were tested for their in vitro sensitivity to cidofovir. The 50% inhibitory concentration for the three parapoxviruses was between 0.21 and 0.27 microg/ml and for vaccinia was 1.32 microg/ml. The selectivity index varied from 198 to 264 for the parapoxviruses and was 42 for vaccinia virus. Virus yield assays confirmed the ability of cidofovir to reduce ortho- and parapoxvirus replication. The efficacy of cidofovir against parapoxviruses justifies its evaluation as a candidate drug for the treatment of parapoxvirus infections in humans and animals.
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Authors | P F Nettleton, J A Gilray, H W Reid, A A Mercer |
Journal | Antiviral research
(Antiviral Res)
Vol. 48
Issue 3
Pg. 205-8
(Dec 2000)
ISSN: 0166-3542 [Print] Netherlands |
PMID | 11164507
(Publication Type: Journal Article)
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Chemical References |
- Antiviral Agents
- Organophosphonates
- Organophosphorus Compounds
- Cytosine
- Cidofovir
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Topics |
- Animals
- Antiviral Agents
(pharmacology)
- Cell Line
- Cidofovir
- Cytosine
(analogs & derivatives, pharmacology)
- Organophosphonates
- Organophosphorus Compounds
(pharmacology)
- Parapoxvirus
(drug effects, physiology)
- Poxviridae Infections
(virology)
- Sheep
- Vaccinia
(virology)
- Vaccinia virus
(drug effects)
- Virus Replication
(drug effects)
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