Glyoxalase I phenotype as a potential risk factor for prostate carcinoma.

Abstract

OBJECTIVES:

To elicit a possible link between glyoxalase I (Gly-I), a detoxifying enzyme, and the incidence of prostate cancer (PCa), we investigated Gly-I phenotypic expression in the prostatic tissue and red blood cells (RBCs) from patients with PCa.

METHODS:

Eighty-seven clinical specimens, including 42 PCa tissue samples, 20 RBC samples, and 25 matched pair (prostate and RBC) samples from patients at prostatectomy were examined. The Gly-I phenotypes in these specimens were assessed by nondenaturing starch-polyacrylamide gel electrophoresis.

RESULTS:

Of the 87 patients, 63 (72.4%) were white, 15 (17.2%) were black, and 9 (10.4%) were another ethnicity (eg, Hispanic, Asian, Indian). Three Gly-I phenotypes were detected in these specimens as fast, intermediate, and slow-moving bands on the gel. The fast phenotype was the most common form found in the white (34 [54%] of 63) and black (8 [53.3%] of 15) patients, but the third ethnic group was too small for proper analysis. To validate this finding, the data from the white patients were compared with the Gly-I phenotypic frequencies in U.S. populations. The data analysis confirmed that a higher incidence (54%) of the fast type in our white patients was statistically significant (P <0.0001) compared with its phenotypic frequency of 30.6% in the general U.S. white population.

CONCLUSIONS:

The significantly high frequency (P <0.0001) of the fast Gly-I phenotype was detected among patients with PCa, suggesting it is a potential risk factor for PCa. Whether its increased incidence in whites reflects the lack of sample numbers for other ethnic groups needs additional investigation.

• Authors: A A Samadi, S A Fullerton, D G Tortorelis, G B Johnson, S D Davidson, M S Choudhury, C Mallouh, H Tazaki, S Konno
• Journal: Urology (Urology) Vol. 57 Issue 1 Pg. 183-7 (Jan 2001) ISSN: 1527-9995 [Electronic] United States
• PMID: 11164178 (Publication Type: Journal Article)

Chemical References

• ABO Blood-Group System
• Neoplasm Proteins
• Lactoylglutathione Lyase

Topics

• ABO Blood-Group System
• Aged
• Black People
• Electrophoresis, Polyacrylamide Gel
• Erythrocytes (enzymology)
• Humans
• Lactoylglutathione Lyase (genetics)
• Male
• Neoplasm Proteins (genetics)
• Phenotype
• Prostatic Neoplasms (enzymology, ethnology, genetics)
• Risk Factors
• White People