Abstract | BACKGROUND: METHODS: The median age at diagnosis was 1.8 years (range 3 weeks to 7 years). Two children presented with severe infantile oxalosis at 3 and 9 weeks, five patients had ESRF with nephrocalcinosis and systemic oxalosis, (median duration of dialysis 1.3 years), and one had progressive chronic renal failure. Four children underwent combined LKT, one child staged liver then kidney, and one infant had an isolated liver transplant. The median age at transplantation was 8.9 years (range 1.7-15 years). RESULTS: Overall patient survival was four out of six. The two infants with PH1 and severe systemic oxalosis died (2 and 3 weeks post-transplant) due to cardiovascular oxalosis and sepsis. The other four children are well at median follow-up of 10 months (range 6 months to 7.4 years). No child developed hepatic rejection and all have normal liver function. Renal rejection occurred in three patients. Despite maximal medical management, oxalate deposits recurred in all renal grafts, contributing to graft loss in one (one of the infants who died), and significant dysfunction requiring haemodialysis post-transplant for 6 months. CONCLUSIONS:
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Authors | S R Ellis, S A Hulton, P J McKiernan, J de Ville de Goyet, D A Kelly |
Journal | Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association
(Nephrol Dial Transplant)
Vol. 16
Issue 2
Pg. 348-54
(Feb 2001)
ISSN: 0931-0509 [Print] England |
PMID | 11158411
(Publication Type: Journal Article)
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Chemical References |
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Topics |
- Adolescent
- Calcium Oxalate
(metabolism)
- Child
- Child, Preschool
- Female
- Graft Rejection
(etiology, physiopathology)
- Humans
- Hyperoxaluria
(classification, complications, metabolism, surgery)
- Infant
- Infant, Newborn
- Kidney
(metabolism, physiopathology)
- Kidney Failure, Chronic
(etiology, surgery)
- Kidney Transplantation
- Liver Transplantation
- Male
- Nephrocalcinosis
(etiology)
- Recurrence
- Retrospective Studies
- Survival Analysis
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