HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Food-dependent androgen and cortisol secretion by a gastric inhibitory polypeptide-receptor expressive adrenocortical adenoma leading to hirsutism and subclinical Cushing's syndrome: in vivo and in vitro studies.

Abstract
Aberrant gastric inhibitory polypeptide (GIP) receptor expression in bilaterally hyperplastic adrenals or unilateral adrenal adenomas is a rare form of adrenal hyperfunction. So far, only few cases have been described. In all these cases, cortisol was the predominant steroid released in a food-dependent manner, leading to the development of non-ACTH-dependent Cushing's syndrome. In the present study, we describe a novel case of a GIP receptor-expressive adrenocortical adenomatous nodule, detected incidentally by computed tomography scanning in a 41-yr-old lady with hirsutism but no clinical signs of Cushing's syndrome, on physical examination. Hormonal investigations in morning fasting samples showed slightly elevated androgen levels, low-normal baseline cortisol, normal suppression of cortisol after dexamethasone administration, and ACTH levels that were not suppressed and did stimulate after CRH administration. The elevated urinary free cortisol excretion, in conjunction with an atypical cortisol diurnal rhythm, raised the possibility of an aberrant stimulation of cortisol production by the adrenal tumor. Further studies demonstrated food-dependent secretion of cortisol, which was abolished by prior octreotide administration. Notably, substantial amounts of adrenal androgens were also secreted after food consumption. Removal of the tumor resulted in undetectable cortisol and androgen levels that did not respond to food consumption. Histological examination of the excised tumor revealed an adrenocortical adenomatous nodule originating from the inner zona reticularis, consisting mainly of compact cells. A steroidogenic secretory pattern, indicating the concomitant release of adrenal androgens and cortisol, was also observed in vitro from tumor cells cultured in the presence of GIP. The in vitro secretory response to GIP was higher for the adrenal androgen DHEA, compared with cortisol. The expression of the GIP receptor in tumor cells, but not in the adjacent normal adrenal, was demonstrated by RT-PCR), using specific oligonucleotide probes for this receptor. In summary, we describe a patient with a GIP-expressive cortisol and androgen oversecreting adrenocortical nodule with the unusual presentation of hirsutism and not the typical clinical signs of Cushing's syndrome. It is of note that food intake in this patient provoked a substantial increase in both adrenal androgen and cortisol levels that, together with the histological appearance of this nodule, was compatible with a zona reticularis-derived tumor. Thus, aberrant expression of the GIP receptor does not exclusively involve cells of a zona fasciculata phenotype, as previously reported, but may also occur in other types of differentiated adrenocortical cells.
AuthorsS Tsagarakis, C Tsigos, V Vassiliou, P Tsiotra, H Pratsinis, D Kletsas, P Trivizas, A Nikou, T Mavromatis, F Sotsiou, S Raptis, N Thalassinos
JournalThe Journal of clinical endocrinology and metabolism (J Clin Endocrinol Metab) Vol. 86 Issue 2 Pg. 583-9 (Feb 2001) ISSN: 0021-972X [Print] United States
PMID11158012 (Publication Type: Case Reports, Journal Article)
Chemical References
  • Androgens
  • Receptors, Gastrointestinal Hormone
  • Dehydroepiandrosterone
  • 17-alpha-Hydroxyprogesterone
  • Adrenocorticotropic Hormone
  • gastric inhibitory polypeptide receptor
  • Octreotide
  • Hydrocortisone
Topics
  • 17-alpha-Hydroxyprogesterone (blood)
  • Adenoma (blood, pathology, physiopathology, surgery)
  • Adrenal Cortex Neoplasms (blood, pathology, physiopathology, surgery)
  • Adrenocorticotropic Hormone (pharmacology)
  • Adult
  • Androgens (blood, metabolism)
  • Circadian Rhythm
  • Cushing Syndrome (etiology, physiopathology)
  • Dehydroepiandrosterone (blood)
  • Eating
  • Female
  • Hirsutism (etiology, physiopathology)
  • Humans
  • Hydrocortisone (blood, metabolism)
  • Octreotide
  • Receptors, Gastrointestinal Hormone (analysis, genetics)
  • Reverse Transcriptase Polymerase Chain Reaction

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: