Abstract | BACKGROUND: METHODS AND RESULTS: CONCLUSIONS: These observations suggested that TNF-alpha is necessary for adhesion molecule expression and to recruit leukocytes to inflammatory sites, and thus, the lack of this cytokine resulted in failure of elimination of infectious agents. We concluded that TNF-alpha plays a protective role in the acute stage of viral myocarditis.
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Authors | H Wada, K Saito, T Kanda, I Kobayashi, H Fujii, S Fujigaki, N Maekawa, H Takatsu, H Fujiwara, K Sekikawa, M Seishima |
Journal | Circulation
(Circulation)
Vol. 103
Issue 5
Pg. 743-9
(Feb 06 2001)
ISSN: 1524-4539 [Electronic] United States |
PMID | 11156888
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- RNA, Messenger
- Tumor Necrosis Factor-alpha
- L-Lactate Dehydrogenase
- Alanine Transaminase
- Creatine Kinase
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Topics |
- Acute Disease
- Alanine Transaminase
(metabolism)
- Analysis of Variance
- Animals
- Blood Urea Nitrogen
- Creatine Kinase
(metabolism)
- Disease Models, Animal
- Female
- Immunohistochemistry
- L-Lactate Dehydrogenase
(metabolism)
- Mice
- Mice, Inbred C57BL
- Myocarditis
(enzymology, metabolism, prevention & control, virology)
- RNA, Messenger
(metabolism)
- Reverse Transcriptase Polymerase Chain Reaction
- Tumor Necrosis Factor-alpha
(metabolism, therapeutic use)
- Viral Load
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