HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

[Proteinases and antiproteinases: biomedical correlations].

Abstract
Both degradative and limited proteolysis are involved in physiological processes. Once activated, proteinases are controlled by endogenous inhibitors (antiproteinases). A variety of genetic disorders and exogenous microbial proteinases disturb the balance between proteinases and cognate inhibitors. alpha 1-Antitrypsin deficiency is a model disorder resulting in an insufficient control of leukocyte elastase with a subsequent alveolar tissue damage. It appears that the manifold molar excess of inhibitor required to compensate the deficiency, is the consequence of both the local relative inaccessibility of the serpin, and the mode of proteinase-serpin interaction, in accord with the "branched pathway" mechanism. Slow-binding kinetics and the leak of native proteinase from the complex is illustrated by the peptidolytic action of porcine elastase in the presence of human alpha 1-antitrypsin and by gelatin zymography, respectively. (Tab. 2, Fig. 5, Ref. 44.)
AuthorsJ Kotyza
JournalBratislavske lekarske listy (Bratisl Lek Listy) Vol. 101 Issue 8 Pg. 445-9 ( 2000) ISSN: 0006-9248 [Print] Slovakia
Vernacular TitleProteinázy a antiproteinázy: biomedicinské korelace.
PMID11153169 (Publication Type: English Abstract, Journal Article)
Chemical References
  • Protease Inhibitors
  • Endopeptidases
Topics
  • Endopeptidases (metabolism)
  • Protease Inhibitors (metabolism)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: