Abstract | OBJECTIVE: To determine the cardiorespiratory effects of preemptive atropine administration in dogs sedated with medetomidine. DESIGN: Randomized crossover trial. ANIMALS: 12 healthy adult dogs. PROCEDURES: Dogs underwent 6 treatments. Each treatment consisted of administration of atropine (0.04 mg/kg [0.018 mg/lb] of body weight, IM) or saline solution ( 0.9% NaCl, 1 ml, IM) and administration of medetomidine (10, 20, or 40 microg/kg [4.5, 9.1, or 18.2 microg/lb], IM) 10 minutes later. Treatments were administered in random order, with a minimum of 1 week between treatments. Cardiorespiratory effects before and after atropine and medetomidine administration were assessed. Duration of lateral recumbency and quality of sedation and recovery were assessed. RESULTS: CONCLUSIONS AND CLINICAL RELEVANCE:
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Authors | J C Ko, S M Fox, R E Mandsager |
Journal | Journal of the American Veterinary Medical Association
(J Am Vet Med Assoc)
Vol. 218
Issue 1
Pg. 52-8
(Jan 01 2001)
ISSN: 0003-1488 [Print] United States |
PMID | 11149715
(Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Chemical References |
- Adrenergic alpha-Agonists
- Muscarinic Antagonists
- Atropine
- Medetomidine
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Topics |
- Adrenergic alpha-Agonists
(administration & dosage, pharmacology)
- Animals
- Atropine
(administration & dosage, pharmacology)
- Blood Pressure
(drug effects)
- Bradycardia
(chemically induced, prevention & control, veterinary)
- Cross-Over Studies
- Cyanosis
(veterinary)
- Dog Diseases
(chemically induced, physiopathology, prevention & control)
- Dogs
(physiology)
- Female
- Heart Rate
(drug effects)
- Linear Models
- Medetomidine
(administration & dosage, pharmacology)
- Muscarinic Antagonists
(administration & dosage, pharmacology)
- Tongue
(pathology)
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