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Conventional and power spectrum analysis of the effects of zolpidem on sleep EEG in patients with chronic primary insomnia.

AbstractSTUDY OBJECTIVE:
The purpose of this study was 1) to assess the effect of zolpidem or a placebo on sleep in two groups of insomniac patients with a diagnosis of moderate-to-severe chronic primary insomnia and 2) to determine the effect of zolpidem on sleep structure using spectral analysis.
DESIGN:
A randomized, double-blind, placebo-controlled trial.
SETTING:
Sleep laboratory of the Department of Pharmacology and Therapeutics at the Clinics Hospital.
PARTICIPANTS:
12 female outpatients with chronic primary insomnia.
INTERVENTIONS:
Zolpidem was given at a daily dose of 10 mg for 15 nights.
RESULTS:
The hypnotic drug reduced sleep latency and waking time after sleep onset, and increased total sleep time and sleep efficiency. Values corresponding to visually scored slow wave sleep (stage 3 and 4) showed no significant changes. All-night spectral analysis of the EEG revealed that power density in NREM sleep was significantly increased in the low frequency band (0.25-1.0 Hz) in the zolpidem group during the first 2-h interval.
CONCLUSIONS:
In agreement with previous findings obtained in patients with chronic primary insomnia, zolpidem significantly improved sleep induction and maintenance. Moreover, zolpidem increased power density in the 0.25-1.0 Hz band during short-term and intermediate-term treatment. Nevertheless, other frequency bands in the delta range showed a relative decrease which was not statistically significant.
AuthorsJ M Monti, F Alvariño, D Monti
JournalSleep (Sleep) Vol. 23 Issue 8 Pg. 1075-84 (Dec 15 2000) ISSN: 0161-8105 [Print] United States
PMID11145322 (Publication Type: Clinical Conference, Clinical Trial, Journal Article, Randomized Controlled Trial)
Chemical References
  • Hypnotics and Sedatives
  • Pyridines
  • zolpidem
Topics
  • Adult
  • Analysis of Variance
  • Brain (drug effects, physiopathology)
  • Double-Blind Method
  • Electroencephalography
  • Female
  • Humans
  • Hypnotics and Sedatives (therapeutic use)
  • Pyridines (therapeutic use)
  • Reaction Time (drug effects, physiology)
  • Sleep (drug effects, physiology)
  • Sleep Initiation and Maintenance Disorders (drug therapy, physiopathology)
  • Wakefulness (drug effects, physiology)

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