Abstract | STUDY OBJECTIVE: The purpose of this study was 1) to assess the effect of zolpidem or a placebo on sleep in two groups of insomniac patients with a diagnosis of moderate-to-severe chronic primary insomnia and 2) to determine the effect of zolpidem on sleep structure using spectral analysis. DESIGN: A randomized, double-blind, placebo-controlled trial. SETTING: Sleep laboratory of the Department of Pharmacology and Therapeutics at the Clinics Hospital. PARTICIPANTS: INTERVENTIONS:
Zolpidem was given at a daily dose of 10 mg for 15 nights. RESULTS: The hypnotic drug reduced sleep latency and waking time after sleep onset, and increased total sleep time and sleep efficiency. Values corresponding to visually scored slow wave sleep (stage 3 and 4) showed no significant changes. All-night spectral analysis of the EEG revealed that power density in NREM sleep was significantly increased in the low frequency band (0.25-1.0 Hz) in the zolpidem group during the first 2-h interval. CONCLUSIONS: In agreement with previous findings obtained in patients with chronic primary insomnia, zolpidem significantly improved sleep induction and maintenance. Moreover, zolpidem increased power density in the 0.25-1.0 Hz band during short-term and intermediate-term treatment. Nevertheless, other frequency bands in the delta range showed a relative decrease which was not statistically significant.
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Authors | J M Monti, F Alvariño, D Monti |
Journal | Sleep
(Sleep)
Vol. 23
Issue 8
Pg. 1075-84
(Dec 15 2000)
ISSN: 0161-8105 [Print] United States |
PMID | 11145322
(Publication Type: Clinical Conference, Clinical Trial, Journal Article, Randomized Controlled Trial)
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Chemical References |
- Hypnotics and Sedatives
- Pyridines
- Zolpidem
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Topics |
- Adult
- Analysis of Variance
- Brain
(drug effects, physiopathology)
- Double-Blind Method
- Electroencephalography
- Female
- Humans
- Hypnotics and Sedatives
(therapeutic use)
- Pyridines
(therapeutic use)
- Reaction Time
(drug effects, physiology)
- Sleep
(drug effects, physiology)
- Sleep Initiation and Maintenance Disorders
(drug therapy, physiopathology)
- Wakefulness
(drug effects, physiology)
- Zolpidem
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