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[Expression of thrombogenic substances by neoplasms: TF and cancer procoagulant. Pathogenic effects].

Abstract
The paper reviews the current studies on mechanism of thrombo-embolic complications in patients with malignancy. The neoplastic cells can express procoagulants like tissue factor (TF), cancer procoagulant (CP) and others, which induce thrombin formation in blood plasma and cause thrombo-embolic events, disseminated intravascular coagulation and other complications. Both procoagulants are acting via extrinsic pathway--TF makes complexes with factor VII and calcium ions, while CP acts directly on factor X transforming it into active form (Xa). Gynecological tumor-related complications occur in 20-30% patients with ovarian or uterine cancer.
AuthorsM Uszyński
JournalGinekologia polska (Ginekol Pol) Vol. 71 Issue 10 Pg. 1287-92 (Oct 2000) ISSN: 0017-0011 [Print] Poland
Vernacular TitleWytwarzanie substancji trombogennych przez nowotwory: czynnik TF i prokoagulant rakowy. Skutki patogenne.
PMID11143939 (Publication Type: English Abstract, Journal Article, Review)
Chemical References
  • Antineoplastic Agents
  • Thromboplastin
Topics
  • Antineoplastic Agents (adverse effects)
  • Female
  • Humans
  • Neoplasms (complications, metabolism)
  • Ovarian Neoplasms (complications)
  • Thromboembolism (etiology)
  • Thromboplastin (metabolism)
  • Uterine Neoplasms (complications)

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