Abstract | PURPOSE: to evaluate the efficacy and the safety of low dose intraocular tissue plasminogen activator (rt-PA) in the treatment of traumatic hyphema and postoperative fibrinous membrane. METHODS: Six microg to 10 microg of rt-PA was injected into the anterior chamber to treat severe fibrinous postoperative membranes and total traumatic hyphemae. RESULTS: Thirteen eyes of 13 patients were treated. Four cases of traumatic hyphema and 9 cases of fibrinous membranes were included. Complete fibrinolysis within 24 hours was observed in 4 cases (30.8%). A partial success was noted in 7 eyes (53.8%). No beneficial effect was observed in two cases of traumatic hyphema associated with intravitreal hemorrhage after penetrating trauma. No side effect attributable to rt-PA occurred. CONCLUSION: Low dose intraocular rt-PA appears to be safe and effective in the treatment of postoperative fibrinous membrane and endocular hemorrhage limited to the anterior chamber.
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Authors | J F Le Rouic, F Behar-Cohen, M H Nghiem, G Renard, D Chauvaud |
Journal | Journal francais d'ophtalmologie
(J Fr Ophtalmol)
Vol. 23
Issue 10
Pg. 977-83
(Dec 2000)
ISSN: 0181-5512 [Print] France |
Vernacular Title | Intérêt des faibles doses de rt-PA dans les syndromes inflammatoires et hémorragiques du segment antérieur: étude clinique et revue de la littérature. |
PMID | 11139689
(Publication Type: Clinical Trial, Journal Article, Review)
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Chemical References |
- Fibrinolytic Agents
- Recombinant Proteins
- Fibrin
- Tissue Plasminogen Activator
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Topics |
- Adolescent
- Adult
- Aged
- Child
- Eye Injuries
(drug therapy)
- Female
- Fibrin
(metabolism)
- Fibrinolytic Agents
(therapeutic use)
- Humans
- Hyphema
(drug therapy)
- Inflammation
(drug therapy, etiology)
- Male
- Middle Aged
- Ophthalmologic Surgical Procedures
- Postoperative Complications
(drug therapy)
- Recombinant Proteins
(therapeutic use)
- Tissue Plasminogen Activator
(therapeutic use)
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