Effect of lupeol, a pentacyclic triterpene, on the lipid peroxidation and antioxidant status in rat kidney after chronic cadmium exposure.

This study pertains to the role of lupeol, a pentacyclic triterpene, against the toxic manifestations of chronic cadmium exposure. Cadmium is a potent nephrotoxin on prolonged exposure. Cadmium (as cadmium chloride) at a dose of 1 mg kg(-1) body weight was administered subcutaneously for 15 days to rats. This led to an increase in the level of lipid peroxides and a decrease in the level of antioxidants in the kidney. Lupeol, when supplemented at a dosage of 40 mg kg(-1) body weight concurrent with cadmium administration, showed an improvement in the antioxidant status. The level of lipid peroxides also showed a significant decrease, which shows the nephroprotective action of the drug.
AuthorsM Nagaraj, S Sunitha, P Varalakshmi
JournalJournal of applied toxicology : JAT (J Appl Toxicol) 2000 Sep-Oct Vol. 20 Issue 5 Pg. 413-7 ISSN: 0260-437X [Print] England
PMID11139172 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Antioxidants
  • Free Radicals
  • Pentacyclic Triterpenes
  • Triterpenes
  • lupeol
  • Animals
  • Antioxidants (metabolism)
  • Cadmium Poisoning (enzymology, metabolism)
  • Female
  • Free Radicals (metabolism)
  • Kidney (drug effects, enzymology, metabolism)
  • Lipid Peroxidation (drug effects)
  • Pentacyclic Triterpenes
  • Rats
  • Rats, Wistar
  • Triterpenes (toxicity)

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