HOMEPRODUCTSSERVICESCOMPANYCONTACTFAQResearchDictionaryPharmaMobileSign Up FREE or Login

Effect of lupeol, a pentacyclic triterpene, on the lipid peroxidation and antioxidant status in rat kidney after chronic cadmium exposure.

Abstract
This study pertains to the role of lupeol, a pentacyclic triterpene, against the toxic manifestations of chronic cadmium exposure. Cadmium is a potent nephrotoxin on prolonged exposure. Cadmium (as cadmium chloride) at a dose of 1 mg kg(-1) body weight was administered subcutaneously for 15 days to rats. This led to an increase in the level of lipid peroxides and a decrease in the level of antioxidants in the kidney. Lupeol, when supplemented at a dosage of 40 mg kg(-1) body weight concurrent with cadmium administration, showed an improvement in the antioxidant status. The level of lipid peroxides also showed a significant decrease, which shows the nephroprotective action of the drug.
AuthorsM Nagaraj, S Sunitha, P Varalakshmi
JournalJournal of applied toxicology : JAT (J Appl Toxicol) 2000 Sep-Oct Vol. 20 Issue 5 Pg. 413-7 ISSN: 0260-437X [Print] England
PMID11139172 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Antioxidants
  • Free Radicals
  • Pentacyclic Triterpenes
  • Triterpenes
  • lupeol
Topics
  • Animals
  • Antioxidants (metabolism)
  • Cadmium Poisoning (enzymology, metabolism)
  • Female
  • Free Radicals (metabolism)
  • Kidney (drug effects, enzymology, metabolism)
  • Lipid Peroxidation (drug effects)
  • Pentacyclic Triterpenes
  • Rats
  • Rats, Wistar
  • Triterpenes (toxicity)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research network!


Choose Username:
Email:
Password:
Verify Password: