HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

NXY-059, a free radical--trapping agent, substantially lessens the functional disability resulting from cerebral ischemia in a primate species.

AbstractBACKGROUND AND PURPOSE:
NXY-059 is a novel nitrone with free radical-trapping properties that has a considerable neuroprotective effect in rats. We have now examined the efficacy of this drug at reducing long-term functional disability in a primate model of stroke.
METHODS:
Twelve monkeys were trained and tested on a variety of behavioral tasks used to dissociate and quantify motor and spatial deficits. Five minutes after permanent occlusion of the right middle cerebral artery, monkeys received a 1-mL intravenous infusion of either saline or NXY-059 (28 mg x kg(-1)), and osmotic minipumps, model 2001D, were implanted subcutaneously to provide continuous drug or saline infusion for 48 hours. Drug-filled pumps released NXY-059 at 16 mg x kg(-1) x h(-1). The monkeys were retested 3 and 10 weeks after surgery to assess functional disability. Surgery, behavioral testing, and histology were all done blinded to treatment condition.
RESULTS:
NXY-059-treated monkeys were significantly better at reaching with their hemiparetic arm than were saline-treated monkeys when retested 3 weeks (P:<0.01) and 10 weeks (P:<0.01) after surgery. Drug treatment also significantly lessened the degree of spatial perceptual neglect (P:<0.01), a debilitating though ameliorating consequence of this infarct. NXY-059 treatment reduced the overall amount of brain damage by >50% of saline-treatment values, with similar levels of protection afforded to both white and gray matter.
CONCLUSIONS:
This novel drug has a substantial protective effect, lessening the disability caused by an experimentally induced stroke in a primate species. These findings provide considerable encouragement for the clinical development of NXY-059.
AuthorsJ W Marshall, K J Duffin, A R Green, R M Ridley
JournalStroke (Stroke) Vol. 32 Issue 1 Pg. 190-8 (Jan 2001) ISSN: 1524-4628 [Electronic] United States
PMID11136936 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Benzenesulfonates
  • Free Radical Scavengers
  • Neuroprotective Agents
  • Nitrogen Oxides
  • disufenton sodium
Topics
  • Analysis of Variance
  • Animals
  • Arm (physiopathology)
  • Behavior, Animal (drug effects)
  • Benzenesulfonates
  • Body Temperature (drug effects)
  • Brain (drug effects, pathology, physiopathology)
  • Brain Ischemia (drug therapy, etiology, physiopathology)
  • Callithrix
  • Choice Behavior (drug effects)
  • Disease Models, Animal
  • Free Radical Scavengers (administration & dosage)
  • Hemodynamics (drug effects)
  • Infarction, Middle Cerebral Artery (complications, drug therapy, pathology)
  • Infusions, Intravenous
  • Kinesis (drug effects)
  • Motor Activity (drug effects)
  • Neuroprotective Agents (administration & dosage, pharmacokinetics)
  • Nitrogen Oxides (administration & dosage, blood)
  • Paresis (drug therapy, etiology, physiopathology)
  • Perceptual Disorders (drug therapy, etiology, physiopathology)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: