Tumor initiation by N-acyloxy derivatives of piperidine and N-arylacetamides.

Abstract

Four N-Acetoxy-N-arylacetamides previously found to be local sarcomagens in the rat have been found to be initiators of tumorigenesis in mouse skin. The order of activity was: N-acetoxy-2-acetamidophenanthrene greater than N-acetoxy-4-acetamino-stilbene similar to N-acetoxy-2-acetamido-fluorene greater than N-acetoxy-4-acetamidobiphenyl. Two substituted N-benzoyloxypiperidines previously shown to yield nitrenium ions on solvolysis in methanol also had initiating activity in mouse skin.

• Authors: J D Scribner, T J Slaga
• Journal: Journal of the National Cancer Institute (J Natl Cancer Inst) Vol. 54 Issue 2 Pg. 491-3 (Feb 1975) ISSN: 0027-8874 [Print] United States
• PMID: 1113329 (Publication Type: Journal Article)

Chemical References

• Acetamides
• Benzene Derivatives
• Biphenyl Compounds
• Fluorobenzenes
• Phenanthrenes
• Piperidines
• Stilbenes

Topics

• Acetamides (toxicity)
• Animals
• Benzene Derivatives
• Biphenyl Compounds
• Female
• Fluorobenzenes
• Mice
• Phenanthrenes
• Piperidines (toxicity)
• Precancerous Conditions (chemically induced)
• Skin Neoplasms (chemically induced)
• Stilbenes
• Time Factors