Predictors of extra-articular manifestations in rheumatoid arthritis.

Abstract

OBJECTIVE:

To identify clinical and genetic risk factors for extra-articular manifestations of rheumatoid arthritis (ExRA).

METHODS:

ExRA patients were identified retrospectively using predefined criteria in two hospital-based cohorts of RA patients, and compared to non-extraarticular RA controls from one of the cohorts, matched for disease duration.

RESULTS:

Forty-nine living and thirteen deceased cases of ExRA were identified. Extra-articular disease was predicted by the demonstration of antinuclear antibodies (Odds ratio (OR) 3.6; 95% CI: 1.4-9.1) and the presence of rheumatoid nodules within two years from RA diagnosis (OR 3.4; 95%, CI: 1.1-10.9) or at any time before ExRA onset (OR 2.8; 95% CI: 1.1-7.2). Male sex and rheumatoid factor did not affect the risk of ExRA. Although present in the majority of cases as well as controls, the disease associated HLA-DRB1 subtypes were not significant predictors of ExRA.

CONCLUSION:

Extra-articular manifestations of rheumatoid arthritis in a hospital based population were predicted by antinuclear antibodies and rheumatoid nodules.

• Authors: C Turesson, L Jacobsson, U Bergström, L Truedsson, G Sturfelt
• Journal: Scandinavian journal of rheumatology (Scand J Rheumatol) Vol. 29 Issue 6 Pg. 358-64 ( 2000) ISSN: 0300-9742 [Print] England
• PMID: 11132204 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antibodies, Antinuclear
• HLA-DR Antigens
• HLA-DRB1 Chains

Topics

• Adolescent
• Adult
• Antibodies, Antinuclear (analysis)
• Arthritis, Rheumatoid (complications, immunology)
• Child
• Cohort Studies
• Female
• HLA-DR Antigens (analysis)
• HLA-DRB1 Chains
• Humans
• Male
• Middle Aged
• Prognosis
• Retrospective Studies
• Rheumatoid Nodule (etiology)