Abstract | OBJECTIVE: To determine the effects of dexamethasone on development of IgG subclass responses following vaccination of healthy horses. ANIMALS: 11 mature Thoroughbreds. PROCEDURE: RESULTS: Vaccination resulted in similar antigen-specific serum IgG(T) titers in dexamethasone-treated and control horses. In contrast, although control horses developed IgGa and IgGb responses after vaccination, corticosteroid administration completely inhibited these responses in treated horses. CONCLUSIONS AND CLINICAL RELEVANCE: Cortico steroids can have profound effects on primary immune responses in horses and can significantly affect IgG responses to inactivated vaccines. Corticosteroid treatment regimens commonly used to treat diseases in horses may result induction of a nonprotective IgG subclass response, leaving treated horses susceptible to disease. Additionally, mechanisms regulating IgGa and IgGb responses appear to differ from those regulating IgG(T) responses. Further defining these mechanisms is a critical step in designing effective vaccines, and corticosteroid-induced immunomodulation may be a valuable tool for studying immune responses in horses.
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Authors | J Slack, J M Risdahl, S J Valberg, M J Murphy, B R Schram, D P Lunn |
Journal | American journal of veterinary research
(Am J Vet Res)
Vol. 61
Issue 12
Pg. 1530-3
(Dec 2000)
ISSN: 0002-9645 [Print] United States |
PMID | 11131594
(Publication Type: Journal Article)
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Chemical References |
- Antibodies, Viral
- Immunoglobulin G
- Vaccines, Inactivated
- Viral Vaccines
- Dexamethasone
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Topics |
- Animals
- Antibodies, Viral
(blood)
- Antibody Formation
(drug effects)
- Dexamethasone
(pharmacology)
- Female
- Horses
- Immunoglobulin G
(blood, classification)
- Male
- Skin Tests
- Time Factors
- Vaccines, Inactivated
- Viral Vaccines
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