Abstract | BACKGROUND:
Prostacyclin has proved to be a beneficial treatment for patients with severe pulmonary hypertension. We postulated that the response may reflect, at least in part, inhibition of pulmonary artery smooth muscle cell (PASMC) growth. METHODS AND RESULTS: CONCLUSIONS: ++ Cicaprost and iloprost inhibit DNA synthesis and proliferation to a greater extent in distal compared with proximal human PASMCs, acting at least in part via a cAMP-dependent mechanism. The results are consistent with the hypothesis that prostacyclin analogues inhibit vascular remodeling in pulmonary hypertension and demonstrate heterogeneity among human PASMCs.
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Authors | J Wharton, N Davie, P D Upton, M H Yacoub, J M Polak, N W Morrell |
Journal | Circulation
(Circulation)
Vol. 102
Issue 25
Pg. 3130-6
(Dec 19 2000)
ISSN: 1524-4539 [Electronic] United States |
PMID | 11120706
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Vasodilator Agents
- DNA
- Epoprostenol
- Cyclic AMP
- Iloprost
- cicaprost
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Topics |
- Adult
- Aged
- Cell Division
- Cells, Cultured
- Cyclic AMP
(biosynthesis)
- DNA
(biosynthesis)
- Depression, Chemical
- Epoprostenol
(analogs & derivatives, pharmacology)
- Female
- Fluorescent Antibody Technique
- Humans
- Iloprost
(pharmacology)
- Male
- Middle Aged
- Muscle, Smooth, Vascular
(anatomy & histology, cytology, drug effects, metabolism)
- Phenotype
- Pulmonary Artery
(anatomy & histology, cytology, drug effects, metabolism)
- Vasodilator Agents
(pharmacology)
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