Abstract | BACKGROUND: METHODS: For this study 36 patients with a low-grade oligodendroglioma treated by surgical resection and radiotherapy were selected. At the time of surgery, in all cases the Karnofsky Performance Scale (KPS) score was more than 70, and the study of the resected tumor disclosed a Ki-67/MIB-1 labeling index (MBI-1 LI) less than 1%. In this homogeneous series, immunohistochemical studies were performed using monoclonal antibodies against VEGF in order to study the expression of this cytokine, and against vascular endothelial CD-34 antigen, in order to identify microvessels. RESULTS: Our results show that in contrast to low-grade astrocytomas, low-grade oligodendrogliomas lacked immunoreactive VEGF. Oligodendrogliomas with low vascular density (less than 20 microvessels per microscopical field, at 200 x) or high vascular density (more than 100 microvessels per field, at 200 x) were identified, but this factor had no influence on the survival rate of patients. On the other hand, analysis of the present series showed that clinical factors, such as age or extent of surgical resection, were not significantly associated with survival. CONCLUSIONS: In contrast to low-grade astrocytomas, the angiogenesis score of low-grade oligodendrogliomas (counting the number of microvessels in tumor tissue) adds little information to help predict tumor behavior.
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Authors | J Vaquero, M Zurita, S Coca, S Oya, C Morales |
Journal | Surgical neurology
(Surg Neurol)
Vol. 54
Issue 3
Pg. 229-34; discussion 234
(Sep 2000)
ISSN: 0090-3019 [Print] United States |
PMID | 11118569
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Antigens, CD34
- Endothelial Growth Factors
- Lymphokines
- Vascular Endothelial Growth Factor A
- Vascular Endothelial Growth Factors
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Topics |
- Antigens, CD34
(metabolism)
- Brain Neoplasms
(blood supply, metabolism, pathology, therapy)
- Endothelial Growth Factors
(metabolism)
- Humans
- Immunohistochemistry
- Karnofsky Performance Status
- Lymphokines
(metabolism)
- Neovascularization, Pathologic
(pathology)
- Oligodendroglioma
(blood supply, metabolism, pathology, therapy)
- Prognosis
- Survival Analysis
- Vascular Endothelial Growth Factor A
- Vascular Endothelial Growth Factors
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