Failure of cidofovir therapy in progressive multifocal leukoencephalopathy unrelated to human immunodeficiency virus.

Abstract

We describe the first reported human immunodeficiency virus (HIV)-seronegative patient treated with cidofovir for progressive multifocal leukoencephalopathy (PML). Marked clinical and radiological progression of PML occurred during cidofovir therapy. The improvement observed during cidofovir therapy of HIV-infected patients may be due to the effect of concomitant antiretroviral therapy rather than cidofovir.

• Authors: S Houston, N Roberts, L Mashinter
• Journal: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America (Clin Infect Dis) Vol. 32 Issue 1 Pg. 150-2 (Jan 2001) ISSN: 1058-4838 [Print] United States
• PMID: 11112674 (Publication Type: Case Reports, Journal Article)

Chemical References

• Anti-HIV Agents
• Organophosphonates
• Organophosphorus Compounds
• Cytosine
• Cidofovir

Topics

• Anti-HIV Agents (therapeutic use)
• Brain (pathology)
• Cidofovir
• Cytosine (analogs & derivatives, therapeutic use)
• Female
• HIV Infections
• Humans
• Leukoencephalopathy, Progressive Multifocal (drug therapy, pathology)
• Magnetic Resonance Imaging (methods)
• Middle Aged
• Organophosphonates
• Organophosphorus Compounds (therapeutic use)
• Treatment Failure