[Protective effect of cycloferon in experimental influenza].

Abstract

Protective effect of granulated cycloferon has been studied in albino mice infected with influenza. The drug induced interferon production and prolonged the life span, decreased the mortality, suppressed the virus reproduction in the lungs, and decreased the infective activity of the virus. Morphologically the drug decreased the intensity of viral lesions in the bronchiolar epithelium, impeded the infection dissemination, and stimulated the productive (cellular) component of local inflammatory reaction. No influence on the development of chronic lesions in the lungs was detected.

• Authors: V P Sukhinin, V V Zarubaev, V G Platonov, A L Kovalenko, F I Ershov
• Journal: Voprosy virusologii (Vopr Virusol) 2000 Sep-Oct Vol. 45 Issue 5 Pg. 26-30 ISSN: 0507-4088 [Print] Russia (Federation)
• Vernacular Title: Zashchitnoe de'istvietsikloferona pri éksperimental'no'i grippozno'i infektsii.
• PMID: 11107650 (Publication Type: Journal Article)

Chemical References

• Acridines
• Interferon Inducers
• 10-carboxymethyl-9-acridanone

Topics

• Acridines (administration & dosage)
• Administration, Oral
• Animals
• Influenza A virus (drug effects)
• Interferon Inducers (administration & dosage)
• Lung (pathology, virology)
• Mice
• Orthomyxoviridae Infections (drug therapy, pathology)