Pregnancy in a woman with a Y chromosome after removal of an ovarian dysgerminoma.

Abstract

BACKGROUND:

It appears to be a general belief that pregnancy might be impossible in women with the XY karyotype. Therefore, it is recommended that patients with dysgerminoma of the ovary associated with the XY karyotype should undergo a bilateral salpingo-oophorectomy.

CASE:

We report an extremely rare case of a true hermaphrodite with a 20% 46,XX/80% 46,XY karyotype who became pregnant after removal of an ovarian dysgerminoma. The patient had a completely normal female phenotype. A dysgerminoma with ovotestis was found in the right ovary. Two courses of chemotherapy following a right salpingo-oophorectomy were carried out. Nine months later she became pregnant and delivered a healthy male infant.

CONCLUSION:

A unilateral salpingo-oophorectomy followed by combination chemotherapy can be the treatment of choice for any woman who wishes to preserve her capacity for conception at the time of operation for dysgerminoma of the ovary.

• Authors: Y Tanaka, K Fujiwara, H Yamauchi, Y Mikami, I Kohno
• Journal: Gynecologic oncology (Gynecol Oncol) Vol. 79 Issue 3 Pg. 519-21 (Dec 2000) ISSN: 0090-8258 [Print] United States
• PMID: 11104633 (Publication Type: Case Reports, Journal Article)
• Copyright: Copyright 2000 Academic Press.

Topics

• Adolescent
• Disorders of Sex Development (genetics)
• Dysgerminoma (genetics, surgery)
• Female
• Humans
• Karyotyping
• Ovarian Neoplasms (genetics, surgery)
• Pregnancy
• Pregnancy Complications, Neoplastic (etiology)