Preliminary results of a randomized radiotherapy dose-escalation study comparing 70 Gy with 78 Gy for prostate cancer.

Abstract

PURPOSE:

To determine the effect of radiotherapy dose on prostate cancer patient outcome and biopsy positivity in a phase III trial.

PATIENTS AND METHODS:

A total of 305 stage T1 through T3 patients were randomized to receive 70 Gy or 78 Gy of external-beam radiotherapy between 1993 and 1998. Of these, 301 were assessable; stratification was based on pretreatment prostate-specific antigen level (PSA). Dose was prescribed to the isocenter at 2 Gy per fraction. All patients underwent planning pelvic computed tomography scan to confirm prostate position. Treatment failure was defined as an increasing PSA on three consecutive follow-up visits or the initiation of salvage treatment. Median follow-up was 40 months.

RESULTS:

One hundred fifty patients were randomized to the 70-Gy arm and 151 to the 78-Gy arm. The difference in freedom from biochemical and/or disease failure (FFF) rates of 69% and 79% for the 70-Gy and 78-Gy groups, respectively, at 5 years was marginally significant (log-rank P: =.058). Multiple-covariate Cox proportional hazards regression showed that the study randomization was an independent correlate of FFF, along with pretreatment PSA, Gleason score, and stage. The patients who benefited most from the 8-Gy dose escalation were those with a pretreatment PSA of more than 10 ng/mL; 5-year FFF rates were 48% and 75% (P: =.011) for the 70-Gy and 78-Gy arms, respectively. There was no difference between the arms ( approximately 80% 5-year FFF) when the pretreatment PSA was < or = 10 ng/mL.

CONCLUSION:

A modest dose increase of 8 Gy using conformal radiotherapy resulted in a substantial improvement in prostate cancer FFF rates for patients with a pretreatment PSA of more than 10 ng/mL. These findings document that local persistence of prostate cancer in intermediate- to high-risk patients is a major problem when doses of 70 Gy or less are used.

• Authors: A Pollack, G K Zagars, L G Smith, J J Lee, A C von Eschenbach, J A Antolak, G Starkschall, I Rosen
• Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology (J Clin Oncol) Vol. 18 Issue 23 Pg. 3904-11 (Dec 01 2000) ISSN: 0732-183X [Print] United States
• PMID: 11099319 (Publication Type: Clinical Trial, Clinical Trial, Phase III, Comparative Study, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, Non-P.H.S., Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Prostate-Specific Antigen

Topics

• Disease-Free Survival
• Dose-Response Relationship, Radiation
• Humans
• Male
• Multivariate Analysis
• Neoplasm Staging
• Palpation
• Proportional Hazards Models
• Prospective Studies
• Prostate-Specific Antigen (blood)
• Prostatic Neoplasms (diagnostic imaging, immunology, radiotherapy)
• Radiotherapy Dosage
• Survival Analysis
• Ultrasonography