What you should know about PR3-ANCA. Evidence for the role of T cells in the pathogenesis of systemic vasculitis.

Abstract

The pathogenesis of systemic vasculitis is complex and is likely to involve many mechanisms. There is a growing body of evidence that T cells may contribute to the pathogenesis of anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitides. Predominantly, T cells and monocytes are found in inflammatory infiltrates in patients with Wegener's granulomatosis (WG). The production of ANCA appears to be T-cell-dependent. T lymphocytes from the peripheral blood of patients with ANCA-associated vasculitis have been shown to proliferate in response to proteinase 3 (PR3). These and other findings outlined in this review indicate T-cell involvement, although further studies are still needed to elucidate the exact contribution of T cells to the pathogenesis of systemic vasculitis.

• Authors: A R Clayton, C O Savage
• Journal: Arthritis research (Arthritis Res) Vol. 2 Issue 4 Pg. 260-2 ( 2000) ISSN: 1465-9905 [Print] England
• PMID: 11094438 (Publication Type: Journal Article, Review)

Chemical References

• Antibodies, Antineutrophil Cytoplasmic
• Cytokines
• Receptors, Antigen, T-Cell
• Serine Endopeptidases
• Myeloblastin

Topics

• Animals
• Antibodies, Antineutrophil Cytoplasmic (immunology, metabolism)
• Cytokines (immunology, metabolism)
• Humans
• Myeloblastin
• Receptors, Antigen, T-Cell (genetics)
• Serine Endopeptidases (immunology, metabolism)
• T-Lymphocytes (immunology, metabolism)
• Vasculitis (immunology, physiopathology)