What you should know about PR3-ANCA. Evidence for the role of T cells in the pathogenesis of systemic vasculitis.

The pathogenesis of systemic vasculitis is complex and is likely to involve many mechanisms. There is a growing body of evidence that T cells may contribute to the pathogenesis of anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitides. Predominantly, T cells and monocytes are found in inflammatory infiltrates in patients with Wegener's granulomatosis (WG). The production of ANCA appears to be T-cell-dependent. T lymphocytes from the peripheral blood of patients with ANCA-associated vasculitis have been shown to proliferate in response to proteinase 3 (PR3). These and other findings outlined in this review indicate T-cell involvement, although further studies are still needed to elucidate the exact contribution of T cells to the pathogenesis of systemic vasculitis.
AuthorsA R Clayton, C O Savage
JournalArthritis research (Arthritis Res) Vol. 2 Issue 4 Pg. 260-2 ( 2000) ISSN: 1465-9905 [Print] England
PMID11094438 (Publication Type: Journal Article, Review)
Chemical References
  • Antibodies, Antineutrophil Cytoplasmic
  • Cytokines
  • Receptors, Antigen, T-Cell
  • Serine Endopeptidases
  • Myeloblastin
  • Animals
  • Antibodies, Antineutrophil Cytoplasmic (immunology, metabolism)
  • Cytokines (immunology, metabolism)
  • Humans
  • Myeloblastin
  • Receptors, Antigen, T-Cell (genetics)
  • Serine Endopeptidases (immunology, metabolism)
  • T-Lymphocytes (immunology, metabolism)
  • Vasculitis (immunology, physiopathology)

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