Intranasal midazolam as an alternative to general anaesthesia in the management of children with oral and maxillofacial trauma.

Abstract

The study assessed the dosage, clinical sedative effect, and safety of intranasal midazolam in 32 children. Data were complete for 29 patients (21 with lacerations and 8 cases of dental trauma). Sedation was adequate to ensure successful completion of treatment under local with or without topical anaesthetic in 22 of the 29 cases (76%). They became sedated at a mean (SD) of 14 (5) minutes, with completion of treatment at 20 (13) minutes. Sedation was achieved with a mean (SD) of 5 (2)mg of midazolam. There were no signs of respiratory depression or of oxygen desaturation below 94% on pulse oximetry. No supplemental oxygen was required and there were no other complications. We conclude that intranasal midazolam is a safe and effective alternative to general anaesthesia in the definitive treatment of children with oral and maxillofacial injuries.

• Authors: C J Lloyd, T Alredy, J C Lowry
• Journal: The British journal of oral & maxillofacial surgery (Br J Oral Maxillofac Surg) Vol. 38 Issue 6 Pg. 593-595 (Dec 2000) ISSN: 0266-4356 [Print] Scotland
• PMID: 11092772 (Publication Type: Clinical Trial, Journal Article)
• Copyright: Copyright 2000 The British Association of Oral and Maxillofacial Surgeons.

Chemical References

• Hypnotics and Sedatives
• Midazolam

Topics

• Administration, Intranasal
• Anesthesia, Dental (methods)
• Child
• Child, Preschool
• Conscious Sedation (methods)
• Facial Injuries (surgery)
• Female
• Humans
• Hypnotics and Sedatives (administration & dosage)
• Infant
• Male
• Midazolam (administration & dosage)
• Tooth Injuries (surgery)