Abstract | OBJECTIVES: We examined effects of immunoglobulin on murine myocarditis induced by encephalomyocarditis virus, not pathogenic to humans, and analyzed the plasma cytokine and catecholamine levels and the changes of the extracellular matrix with or without the treatment. BACKGROUND: We have previously shown that immunoglobulin therapy suppressed murine coxsackievirus B3 myocarditis by an antiviral effect. However, it is not yet determined whether beneficial effects of immunoglobulin for myocarditis are due to antiviral effects or to other unknown effects. METHODS:
Antiviral activity of human immunoglobulin ( Polyglobin-N) against encephalomyocarditis virus was determined in vitro. Immunoglobulin (1 g/kg/day) was administered intraperitoneally to the virus-infected mice daily for two weeks, beginning simultaneously with virus inoculation in experiment I and on day 14 after virus inoculation in experiment II. RESULTS: CONCLUSIONS: Immunoglobulin therapy could suppress myocarditis associated with the improvement of extracellular matrix changes by the reduction of neurohumoral activity.
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Authors | C Kishimoto, N Takamatsu, H Kawamata, H Shinohara, H Ochiai |
Journal | Journal of the American College of Cardiology
(J Am Coll Cardiol)
Vol. 36
Issue 6
Pg. 1979-84
(Nov 15 2000)
ISSN: 0735-1097 [Print] United States |
PMID | 11092674
(Publication Type: Evaluation Study, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Immunoglobulins, Intravenous
- Intercellular Adhesion Molecule-1
- Interferon-gamma
- Norepinephrine
- Epinephrine
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Topics |
- Animals
- Cardiovirus Infections
(blood, pathology, prevention & control)
- Encephalomyocarditis virus
- Enzyme-Linked Immunosorbent Assay
- Epinephrine
(blood)
- Extracellular Matrix
(pathology)
- Immunoglobulins, Intravenous
(therapeutic use)
- Intercellular Adhesion Molecule-1
(blood)
- Interferon-gamma
(blood)
- Male
- Mice
- Mice, Inbred DBA
- Myocardium
(pathology)
- Necrosis
- Norepinephrine
(blood)
- Random Allocation
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