HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Pharmacogenetics and adverse drug reactions.

Abstract
Polymorphisms in the genes that code for drug-metabolising enzymes, drug transporters, drug receptors, and ion channels can affect an individual's risk of having an adverse drug reaction, or can alter the efficacy of drug treatment in that individual. Mutant alleles at a single gene locus are the best studied individual risk factors for adverse drug reactions, and include many genes coding for drug-metabolising enzymes. These genetic polymorphisms of drug metabolism produce the phenotypes of "poor metabolisers" or "ultrarapid metabolisers" of numerous drugs. Together, such phenotypes make up a substantial proportion of the population. Pharmacogenomic techniques allow efficient analysis of these risk factors, and genotyping tests have the potential to optimise drug therapy in the future.
AuthorsU A Meyer
JournalLancet (London, England) (Lancet) Vol. 356 Issue 9242 Pg. 1667-71 (Nov 11 2000) ISSN: 0140-6736 [Print] England
PMID11089838 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)
Chemical References
  • Pharmaceutical Preparations
  • Receptors, Drug
Topics
  • Drug-Related Side Effects and Adverse Reactions (genetics)
  • Humans
  • Mutation
  • Pharmaceutical Preparations (metabolism)
  • Pharmacogenetics
  • Polymorphism, Genetic
  • Receptors, Drug (genetics)
  • Risk Factors

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: