Abstract | OBJECTIVE: METHODS: The VEGF and bFGF concentrations in cultured synoviocytes and peripheral blood from patients with RA were measured by enzyme-linked immunosorbent assay and their serum concentrations were measured at two time points. RESULTS: BUC and GST inhibited VEGF production even when given alone, and a combination of BUC, GST and MTX with DEX also inhibited VEGF production. None of the DMARDs or DEX inhibited bFGF production when given alone, but a combination of SASP and GST inhibited the production of bFGF in cultured synoviocytes. Serum VEGF concentrations were significantly decreased 6 months after the commencement of medication compared with their concentrations before medication. CONCLUSION: Our results show that the effects of a combination of DEX with any two of BUC, GST, SASP and MTX on the production of VEGF and bFGF in cultured synoviocytes and on the serum concentrations of VEGF in patients with RA may be based on synergistic or additive effects of the drugs.
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Authors | M Nagashima, K Wauke, D Hirano, S Ishigami, H Aono, M Takai, M Sasano, S Yoshino |
Journal | Rheumatology (Oxford, England)
(Rheumatology (Oxford))
Vol. 39
Issue 11
Pg. 1255-62
(Nov 2000)
ISSN: 1462-0324 [Print] England |
PMID | 11085806
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Anti-Inflammatory Agents
- Anti-Inflammatory Agents, Non-Steroidal
- Antirheumatic Agents
- Endothelial Growth Factors
- Lipopolysaccharides
- Lymphokines
- Vascular Endothelial Growth Factor A
- Vascular Endothelial Growth Factors
- Fibroblast Growth Factor 2
- Gold Sodium Thiomalate
- Sulfasalazine
- Dexamethasone
- C-Reactive Protein
- Cysteine
- bucillamine
- Methotrexate
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Topics |
- Anti-Inflammatory Agents
(pharmacology)
- Anti-Inflammatory Agents, Non-Steroidal
(pharmacology)
- Antirheumatic Agents
(pharmacology)
- Arthritis, Rheumatoid
(drug therapy, metabolism)
- C-Reactive Protein
(metabolism)
- Cells, Cultured
- Cysteine
(analogs & derivatives, pharmacology)
- Dexamethasone
(pharmacology)
- Drug Synergism
- Drug Therapy, Combination
- Endothelial Growth Factors
(biosynthesis, blood)
- Fibroblast Growth Factor 2
(biosynthesis, blood)
- Gold Sodium Thiomalate
(pharmacology)
- Humans
- In Vitro Techniques
- Lipopolysaccharides
- Lymphokines
(biosynthesis, blood)
- Methotrexate
(pharmacology)
- Sulfasalazine
(pharmacology)
- Synovial Membrane
(cytology, drug effects, metabolism)
- Vascular Endothelial Growth Factor A
- Vascular Endothelial Growth Factors
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